Author

Nobuya Sasaki

3 papers indexed here

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Open access Sep 2026

Remimazolam- and dexmedetomidine-based three-drug mixtures refine injectable anesthesia in mice.

The medetomidine-midazolam-butorphanol mixture (MMB) is widely used for injectable anesthesia in mice but is associated with delayed induction, prolonged recovery, impaired oxygenation, and post-anesthetic hypothermia. We investigated whether substituting midazolam with remimazolam, alone or together with replacing med...

Takeru Sasaki, Masaki Watanabe, Ryuya Nakagawa et al. · Experimental animals · 0 citations

#protein folding Sep 2026

Integrated proteomic-transcriptomic profiling identifies NR3C2 up-regulation and a candidate plasma-protein-handling signature in chronic podocyte injury.

Findings show that the late phase of podocyte-driven CKD involves distributed protein-level remodelling, including an RNA-discordant increase in NR3C2 protein and a candidate plasma-protein-handling signature.

Koichi Ito, Masaki Watanabe, Koyuki Kawamoto et al. · The FEBS Journal · 0 citations

#gene editing Open access Sep 2026

Animal Model Selection and Deep Phenotyping in Mitochondrial Genetic Diseases: Connecting Human Variants, Multisystem Pathology, and Preclinical Evidence

Mitochondrial genetic diseases arise from variants in mitochondrial DNA (mtDNA) or nuclear genes required for mitochondrial function. Although many involve several organs, the predominant clinical manifestations may be confined to particular organs. Experimental models are used to investigate variant pathogenicity, org...

Nobuya Sasaki, Masaki Watanabe · Genes · 0 citations