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Author

Osamede C. Owegie

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Oct 2026

Inhibition of mitochondrial permeability transition selectively suppresses thrombogenic platelet procoagulant activity.

Platelets support coagulation by externalizing phosphatidylserine (PS), creating a catalytic surface for thrombin generation and fibrin formation. Although platelet PS exposure is required for hemostasis, excessive procoagulant platelet activity drives thrombosis. Sustained calcium influx after strong agonist stimulati...

Yi-Heng Zhang, Jordan Sandler, O. Owegie et al. · 0 citations
#protein folding Aug 2026

Molecular mechanisms of protein disulfide isomerase antagonism by punicalagin.

Biochemical oxidase and reductase assays on PDI showed that punicalagin inhibits both activities with micromolar potency, thereby extending earlier work that described disulfide reductase inhibition.

Osamede C. Owegie, Rong-guang Xu, Quinn P. Kennedy et al. · 0 citations

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