mRNA Lipid Nanoparticle Delivery Systems: Composition, Optimization and Advances in Clinical Translation
Lipid nanoparticles (LNP) represent critical non‑viral carriers for mRNA delivery, capable of encapsulating, protecting mRNA, facilitating cellular uptake and enabling cytosolic release. This review summarizes the composition and delivery mechanisms of mRNA‑LNP. Optimization strategies including ionizable lipid structu...