Oct 2026· Theoretical and Natural Science· 0 citations
RNA Interference and Gene Delivery
Abstract
Lipid nanoparticles (LNP) represent critical non‑viral carriers for mRNA delivery, capable of encapsulating, protecting mRNA, facilitating cellular uptake and enabling cytosolic release. This review summarizes the composition and delivery mechanisms of mRNA‑LNP. Optimization strategies including ionizable lipid structure, component ratio tuning, endosomal escape improvement and tissue‑targeted modification are analysed in depth. Its applications in vaccines, tumour therapy, protein replacement and gene‑editing are further outlined. Current bottlenecks contain limited endosomal‑escape efficiency, insufficient extra‑hepatic delivery, safety concerns for repeated administration, and consistency challenges in large‑scale manufacturing. Future efforts should focus on lipid‑structure and formulation optimization, alongside improved safety evaluation and quality‑control frameworks to accelerate clinical translation.
Some claim that especially in the field of agile software development the research lags years behind of the practice. In this paper, we characterize the status and main challenges for research on agile software development, and propose a preliminary roadmap, focusing on providing more empirical research, primarily on e...
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The results indicate that software developers are a slightly happy population, but the need for limiting the unhappiness of developers remains, and 219 factors representing causes of unhappiness while developing software are identified.
D. Graziotin, Fabian Fagerholm, Xiaofeng Wang et al.· International Conference on...· 84 citations· ⚡6
This study investigates how Lean internal startup facilitates software product innovation in large companies and identifies its enablers and inhibitors, and shows the potential of the method-in-action framework to investigate the Lean startup approach in non-startup context.
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The goal is to not only refine the accuracy of the LLM-based tool but also to underscore its potential in streamlining the software development lifecycle through proactive code improvement and education.
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Agile methods continue to gain popularity. In particular, the Scrum method appears to be on the verge of becoming a de-facto standard in the industry, leading the so called Agile movement. While there are success stories and recommendations, there is little scientifically valid evidence of the challenges in the adoptio...
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A comprehensive overview of how enhanced sampling methods are reshaping the field, with a particular focus on the data-driven construction of collective variables, is provided.
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Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
