Author

Qi Zhang

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#protein folding Sep 2026

Glutamine-regulated VCP acetylation creates a proteostasis vulnerability in RB1-deficient tumor

Findings identify glutamine-regulated VCP acetylation as a metabolic–proteostasis dependency in RB1-deficient tumors and nominate VCP inhibition as a therapeutic strategy for this difficult-to-target tumor state.

Bing-Hui Yang, Ying Cao, Yi-Ning Tao et al. · bioRxiv · 0 citations

Aug 2026

DPF3a couples H3K36me2-dependent chromatin remodeling to genome architecture during myogenesis

The findings uncover a non-canonical mechanism whereby a chromatin remodeler regulates transcription primarily through three-dimensional genome organization rather than local accessibility control, and establish histone modification-guided chromatin remodeling as a key principle in gene regulation.

Ming Yu, Jingdong Xue, Qi Zhang et al. · bioRxiv · 0 citations