Author

Qing Yu

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Open access Sep 2026

A multivalent docking platform and Rcn1-mediated inhibition control the extent of calcineurin recruitment to the cell division site for the dephosphorylation of multiple cytokinetic proteins

Recruitment to the cytokinetic ring (CR) requires its PxIxIT- and LxVP-binding surfaces and is mediated by multivalent interactions with the CR components paxillin-like Pxl1 and the F-BAR protein Cdc15, which reveals that CN targets a broad network of structural and signaling components involved in cell division.

Alaina H. Willet, Jun-Song Chen, Qing Yu et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Next-generation multiplexed targeted proteomics quantifies post-translational modifications in disease and compound-protein interactions with high throughput

Improvements enabling quantification of site-specific modifications, including post-translational modifications and covalent compound-protein interactions spanning diverse pathways are described.

Steven R. Shuken, Geordon A. Frere, Charlotte R. Beard et al. · Nature Communications · 0 citations