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Open access Nov 2026

Atractylenolide II Alleviates 5-Fluorouracil-Induced Intestinal Toxicity Through Potentially Targeting the TLR4-Mediated MYD88/NF-κB Signaling Pathway: An Integrated In Silico and In Vitro Study

5-Fluorouracil (5-FU) is a potent compound in anti-tumor chemotherapy; however, its clinical utility is hampered by dose-limiting intestinal toxicity. Atractylenolide II (AT-II), a bioactive sesquiterpene derived from Atractylodis Rhizoma, has reported anti-inflammatory and cytoprotective activities. In this study, we...

Yang-Zhi Liu, Ru Jia, Yue Liu et al. · 0 citations
#protein folding Open access Nov 2026

Self-Assembled Particles from Raw and Bran-Fried Atractylodes lancea Exert Spleen-Strengthening Effects via TFF1/NF-κB Pathway and Gut Microbiota Remodeling

It was revealed that the self-assembled particles reversed SDS-induced gut dysbiosis, characterized by increased abundance of beneficial Dubosiella and decreased abundance of pathogenic Escherichia-Shigella and downregulated TFF1/NF-κB p65 protein expression.

Ming-Yang Cui, Xing-Yi Li, Yang Qu et al. · 0 citations

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