Atractylenolide II Alleviates 5-Fluorouracil-Induced Intestinal Toxicity Through Potentially Targeting the TLR4-Mediated MYD88/NF-κB Signaling Pathway: An Integrated In Silico and In Vitro Study
5-Fluorouracil (5-FU) is a potent compound in anti-tumor chemotherapy; however, its clinical utility is hampered by dose-limiting intestinal toxicity. Atractylenolide II (AT-II), a bioactive sesquiterpene derived from Atractylodis Rhizoma, has reported anti-inflammatory and cytoprotective activities. In this study, we...