Diabetes mellitus is a chronic metabolic disorder associated with persistent hyperglycemia and the development of numerous secondary complications. In the present study, a series of 4-aminochalcone derivatives (1N–10N) were synthesized and evaluated as potential dual inhibitors of α-glucosidase and aldose reductase usi...
E. Mughal, Nafeesa Naeem, Songül Bayrak et al.· RSC Advances· 0 citations
A series of novel quinazolinone-based aldazine and ketazine derivatives (4a–l and 6) was synthesized through the condensation of hydrazine intermediate 2 with substituted aldehydes and isatin using chitosan sulfonic acid (CS–SO3H) as a recyclable heterogeneous catalyst. The reactions were performed under conventional r...
Tariq Z. Abolibda, Yousef R. Alsuhaymi, B. Farag et al.· Catalysts· 0 citations
7f is identified as a promising lead displaying concurrent EGFR and COX-2 inhibitory activity together with pronounced antiproliferative effects, consistent with its experimentally observed dual inhibitory activity.
Abdullah Alkhammash, B. A. Saleem, Khulood H. Oudah et al.· RSC Advances· 0 citations
The combined experimental and computational results demonstrate significant structure-activity relationships within the bis-oxadiazole scaffold, identifying compound 10 as a promising lead candidate for further optimization as a dual enzyme inhibitor for diabetes management.
Shoaib Khan, Tayyiaba Iqbal, B. N. Murtaza et al.· Future Medicinal Chemistry· 0 citations
Sulfite (SO32−) is a significant analyte that is frequently employed as a food and beverage sector preservative but its excessive consumption might lead to negative health effects. Therefore, it is important to develop ultra-sensitive and ultra-selective sulfite detection methods. Herein, we demonstrate the design, syn...
Kazma Batool, T. Al-Warhi, A. Şenol et al.· RSC Advances· 1 citation
