S. Michnick

A strategy for genome-wide seamless tagging of human protein-coding genes

A universal and scalable method based on CRISPR/Cas9-non-homologous end joining (NHEJ) for Pooled Recombinant Integration of Seamless Markers (PRISM) into protein coding genes, paving the way for genome-scale construction of human cell lines tagged with different types of reporter genes for protein functional character...

Genetic landscape of an in vivo protein interactome.

SARS-CoV-2 maturation driven by a mechano-active nucleocapsid-RNA condensate

It is demonstrated that N protein-vgRNA condensates are spontaneously enveloped by lipid bilayer membranes, whereas condensates formed by N protein alone or with genomic RNA fragments fail to undergo envelopment and instead adhere to or weakly deform membranes.