Author

Tao Liu

2 papers indexed here

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Open access Aug 2026

A Tumor-Microenvironment-Responsive Chemically Masked IL‑2 Prodrug Potentiates PD‑1 Checkpoint Blockade and Elicits Robust Antitumor Efficacy

Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables tumor-microenvironment-responsive cytokine activ...

Linzhi Tan, Yuning Yang, Ke-Rui Zhao et al. · ACS Central Science · 0 citations

#protein folding Aug 2026

Engineering inflammation-responsive proteins through nitric oxide-caged amino acids.

This work reports a protein engineering strategy that enables selective restoration of protein function in nitric oxide-rich environments and establishes nitric oxide-triggered chemical reactivation of proteins as a generalizable method for post-translational control of protein function.

Wenkang Cai, Jun-Hao Cui, Zhiying Zeng et al. · Nature Biomedical Engineerin... · 0 citations