Gain-of-function mutations in the RodZ juxtamembrane domain promote Rod system activity in Escherichia coli
The peptidoglycan (PG) cell wall protects bacteria from osmotic lysis and determines their shape. In rod-shaped bacteria, the lateral wall is elongated by the Rod system (elongasome). This synthetic machine is built around the RodA-PBP2 PG synthase complex, the actin-like protein MreB, and the accessory proteins MreC,...