Author

Tuomas P. J. Knowles

3 papers indexed here

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Open access Sep 2026

Charge-driven remodelling of monomeric Tau determines its phase behaviour

Tau transitions from a functional microtubule-stabilising monomer into pathological aggregates in tauopathies. However, the molecular mechanism by which soluble Tau transitions into insoluble aggregates remains poorly understood. Here, we show that modulation of Tau’s internal charge-charge interactions by pH and ionic...

Yudisthira Oktaviandie, Ze-Xiang Han, Katherine Stott et al. · bioRxiv · 0 citations

#protein folding Open access Sep 2026

State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins

Deep learning-based protein design is used to generate de novo binders capturing this region of α-synuclein in a β-strand conformation to establish a set of molecules that target distinct aggregation intermediates and mechanistically reshape αSyn assembly.

Yun-Xuan Zhang, Hannah L. Han, L. Ortigosa-Pascual et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Quantifying molecular specificity in excipient-driven antibody solubilization

It is shown that excipient-mediated solubilization of therapeutic antibodies is markedly molecularly specific, and the integration of high-throughput experimentation with molecular feature analysis offers a foundation for improving the understanding and prediction of antibody-specific formulation behavior.

Zexiang Han, Nadia A. Erkamp, Rob M. Scrutton et al. · mAbs · 0 citations