Heart failure with preserved ejection fraction (HFpEF) represents a predominant heart failure phenotype characterized by intricate pathophysiology and an escalating global prevalence. Beyond classical hemodynamic disturbances, emerging evidence identifies mitochondrial dysfunction as a central mechanism in HFpEF pathog...
Ying An, Cong-Hui Shang, A. M. Abd el-Aty et al.· The Journal of Cardiovascula...· 0 citations
Order and disorder are described through entropy, randomness, uncertainty, and noise, yet these concepts do not explain how observers classify patterns under finite, resolution dependent observations. We propose the Logos framework as a conceptual and formal account of temporally relative order and residual disorder. A...
Orkid Coskuner-Weber, S. Alpsoy, V. Uversky et al.· MetaScientia: Journal of the...· 0 citations
Protein folding is highly sensitive to environmental conditions such as pH, which can influence internal hydrogen bonding and interactions with the solvent, and it is found that pH can shift proteins into or out of the two-state range of k2 values.
Knarik Yeritsyan, V. Uversky, A. Badasyan· Biomolecules· 0 citations
Benchmark evaluations across curated datasets spanning conserved domains, structural motifs, and heterogeneous families demonstrate that BioMatics 1.0 outperforms widely used tools in column score (CS) accuracy and achieves competitive or comparable sum-of-pairs score (SPS) results.
Orkid Coskuner-Weber, Yusuf Emre Ari, Yildiray Efe Berberoglu et al.· Proteins: Structure, Functio...· 2 citations
The data support aqueous solvent interaction analysis as a broadly applicable, mechanistically grounded technology for protein characterization, drug–protein interaction studies, and structure-centric biomarker development, exemplified by the clinical translation of IsoPSA.
B. Zaslavsky, M. Stovsky, V. Uversky· International Journal of Mol...· 0 citations
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