Proteolysis-targeting chimeras (PROTACs) promote targeted protein degradation by inducing a transient ternary complex between a protein of interest and an E3 ubiquitin ligase. Despite the clinical promise of these event-driven therapeutics, defining the conformational landscape and interfacial organization of these com...
Evan N. Whitford, Joshua D. Gilbert, Marius M. Kostelic et al.· bioRxiv· 0 citations
The rational design and characterization of functional T3SS needle binding proteins are reported, establishing a molecular blueprint for the design of functional T3SS needle binding proteins, enabling future efforts to disrupt conserved secretion systems underlying bacterial pathogenesis.
Mechanistic understanding of inter-subunit communication in PRMT1 oligomers is expanded and half-of-sites reactivity is identified as a previously unrecognized regulatory feature that may be leveraged for the development of PRMT1-selective allosteric inhibitors.
Vincent Rossi, Robert S. Wilson-Kovacs, Yuan Gao et al.· Journal of Biological Chemis...· 0 citations
This nMS-based workflow offers a broadly applicable framework for resolving the catalytic states and inter-site communication of oligomeric enzymes that are otherwise difficult to uncover by conventional structural methods.
Yuan Gao, Jamison D. Law, Venkat Gopalan et al.· bioRxiv· 0 citations
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