Cysteine-Inspired Photosensitizer with Efficient Tumor Accumulation Enables Thermoresistance Reversal for Reciprocal Enhancement of Photodynamic-Photothermal Therapy.
Abstract Insufficient tumor accumulation and heat shock protein (HSP)-mediated adaptive resistance remain major barriers to effective cancer therapy. Here, a cysteine-inspired conjugated polymer photosensitizer (CP-PCys) was developed to integrate enhanced tumor accumulation, hydrogen sulfide (H2S) generation, photodyn...