Author

Yan He

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Open access Aug 2026

J-domain proteins bridge the PKL and ATRX complex to transcription factors to fine-tune gene expression via H3.3 deposition

It is found that transcriptional outcome of PKL binding depends not only on the changes in H3.3 occupancy but also on the pre-existing chromatin context at PKL-targeted sites, which outlines a new mechanism for CHD3 chromatin remodeler recruitment and function.

Shu-Ya Wang, Colette L. Picard, Zhong-Shou Wu et al. · bioRxiv · 0 citations

#gene editing Open access Aug 2026

Chromatin-Assisted Targeting Enables Precise DNA Methylation Editing in Plants

SunTag-NOVA robustly installed DNA methylation and repressed transcription at the endogenous FWA, FT and TMM genes with minimal genome-wide off-target consequences, and establishes SunTag-NOVA as a specific epigenome-editing platform for plants.

Yan He, Ming Wang, T. J. Buckley et al. · bioRxiv · 0 citations