Author

Zhi-Xun Guo

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Sep 2026

A hypoxia-derived seven-gene signature reflects immune remodeling in diabetic kidney disease: integrated transcriptomic analysis and experimental validation.

AIMS To develop and assess a hypoxia-associated gene signature for diabetic kidney disease (DKD), and to examine its relationship with immune remodeling and molecular heterogeneity. METHODS GEO renal transcriptomic datasets were integrated to identify hypoxia-related differentially expressed genes. Weighted gene co-e...

Yue Ji, Jia-Kun Zhang, Xi Guo et al. · Diabetes Research and Clinic... · 0 citations

#protein folding Review Open access Aug 2026

Endoplasmic reticulum stress in Hashimoto’s thyroiditis: a candidate amplification node linking thyroid-specific vulnerability and immune dysregulation

A testable positive-feedback perspective in which thyrocyte ERS injury and immune effector amplification may mutually reinforce one another is proposed, in which thyrocyte ERS injury and immune effector amplification may mutually reinforce one another.

X. Si, Zhi-Xun Guo, Ge-Na Jiao et al. · Frontiers in Immunology · 0 citations