diffusion models

Learning Protein Conformational Transitions for Reference-Guided Functional Conformational Modelling

Abstract Accurate protein structure prediction does not necessarily identify the conformational state relevant to a specific biological or pharmacological function. In practice, structural biologists often resolve this ambiguity by drawing on homologous, family-related or ligand-bound reference structures, but this pro...

Digital Innovation in Italian Museums:

This paper examines the adoption of immersive technologies -- Augmented Reality (AR) and Virtual Reality (VR) -- in Italian museums, focusing on how digital tools shape visitor experiences across different regional contexts. Building on earlier exploratory work conducted through online surveys and preliminary field res...

Numerical Characterization and Experimental Optimization of Microfluidic DNA Microarray Hybridization

Background/Objectives: Mathematical modeling and computational simulation are important tools in the analysis of fluid transport phenomena and surface reactions. These include surface hybridization that takes place in a microfluidic channel, creating a DNA microarray. Methods: In this work, the surface hybridization of...

Comparative Analysis of Paroxetine Loaded Nanostructure Lipid Carriers vs Paroxetine Dispersion in LPS Induced Depression Model

The current study was intended to investigate the comparative anti-depressant activity of Paroxetine-entrapped nanostructured lipid carriers (PAR-NLCs) and Paroxetine dispersion (PAR-Dispersion) in lipopolysaccharide (LPS) induced depression model. Previously prepared, PAR-NLCs with the optimal acetyl alcohol to oleic...

A thermodynamically consistent theory of multicomponent porous media: finite-deformation mechanics, compositional flow, electrostatics, reactions, and phase transformations

Reactive reservoir models must combine compositional flow, deformation, electrostatics, chemical reactions, and phase transformations without losing the thermodynamic origin of each term. This paper develops such a theory for multicomponent, multiphase porous media at finite deformation. Component mass conservation is...

THE ROLE OF INTERNATIONAL ORGANIZATIONS IN SHAPING NATIONAL PUBLIC POLICY AND MODERNIZING PUBLIC ADMINISTRATION: AN INTERNATIONAL LEGAL AND INSTITUTIONAL APPROACH

This thesis examines the role of international organizations in shaping national public policy, introducing international standards into domestic legal and policy frameworks, and strengthening the institutional capacity of public administration. Particular attention is given to the United Nations (UN), the World Bank,...

Cold Bias in the Central North Atlantic: Characterization and Heat Budget Analysis from CMIP6 and HighResMIP Simulations

The Central North Atlantic (CNA) sea surface temperature cold bias is a well-documented feature in contemporary climate models, yet its underlying physical causes remain not fully elucidated. Here we systematically characterize the cold bias using historical simulations from the sixth phase of the Coupled Model Interco...

Computational Models of Intracellular Protein Mobility and Condensate Dynamics

To systematically elucidate the multiscale impacts of Min protein oscillations, we constructed a multiscale numerical framework composed of three particle-based modules: MinOscillation, MinDiffusion, and MinPhase. The three modules share unified numerical scales, thereby linking molecular oscillations, diffusion modula...

AI attitudes and organizational learning in distance education: interpreting an AI learning gap through structural equation modeling

Dynamical Localization as Quantum Thinning: A Thinness Ratio for Microwave Hydrogen and the Kicked Rotator

This paper asks a narrower question than whether a quantum system is chaotic. It asks whether quantum transport reaches a stated failure scale over a stated horizon. The setting is dynamical localization, where momentum or photon-number diffusion in a classically chaotic Floquet system stops after a break time because...

Dynamics of bicoid mRNA localisation and translation dictate morphogen gradient formation

Abstract The transcription factor Bicoid (Bcd) protein guides early Drosophila patterning and is the best-characterised morphogen. The source of the morphogen, bcd mRNA, is maternally deposited during oogenesis and localised to the anterior pole. When and where Bcd protein is produced and how this protein gradient is d...

Thermodynamics and Kinetics of Ammonia‐Based Reduction of Natural Hematite

Using hydrogen gas for iron ore reduction offers carbon‐neutral ironmaking, but scaling up faces safety and energy challenges. Ammonia is a safer carbon‐free hydrogen carrier with higher energy density and ease of liquefaction. This study investigates the characteristics of ammonia‐based direct reduction (AmDR) of natu...