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1,701 papers
A multiplex prime-editing platform is developed that converts commonly used immunosuppressive drugs into tools for in vivo control of T-cell therapies via defined, pathway-specific drug resistance, enabling selective in vivo modulation in settings where immunosuppression cannot be withdrawn.
The spectrum of genetic lesions that result in activation of NF‑κB in mature B‑cell malignancies is expanded and highlights the incomplete understanding of NF‑κB drivers in mature B‑cell malignancies.
A critical synthesis of recent advances in pigment regulation is presented, moving beyond descriptive gene lists to examine the mechanistic underpinnings of pigment regulation and provides a foundation for rational manipulation of fruit coloration and nutritional quality.
Tyrosine sulfation is a post-translational modification that has been reported to occur infrequently on recombinant monoclonal antibodies (mAbs). We recently demonstrated that tyrosine sulfation occurred on a bispecific antibody (bsAb) produced in Chinese hamster ovary (CHO) cells, using a multi-enzymatic approach in c...
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Abstract Background MiT/TFE-rearranged, translocation renal cell carcinoma (tRCC) is characterized by gene fusions involving TFE3 or TFEB, and is a rare, aggressive non-ccRCC, often occurring in children and with few biomarkers or targeted therapy options. TFE3 is the most commonly translocated gene with ASPSCR1, PRCC...
ADAR2-mediated A-to-I editing confers an oncogenic role on miR-376a-3p by shifting its target from KPNA4 to HOXD10, thereby facilitating PTC tumorigenesis through enhanced glycolysis.
This article presents a narrative review of CRISPR and the Editing of the Genome in the context of Biology. The literature on this topic has expanded substantially over recent decades, yet it remains fragmented across subfields, methods, and national research traditions. Drawing on an interpretive synthesis of represen...
Maize (Zea mays L.) is one of the most important cereal crops worldwide, playing a fundamental role in food security, animal nutrition, and industrial production. Among the bacterial diseases affecting maize, bacterial stripe caused by Acidovorax avenae subsp. avenae has emerged as a significant phytosanitary concern d...
This study explores the diverse applications of CRISPR, highlighting its role in treating genetic disorders such as sickle cell anemia and Duchenne muscular dystrophy, advancing cancer immunotherapies, and developing CRISPR-based antiviral therapies for HIV and COVID-19.
Meeting the increasing demand for safe, nutritious, and climate-resilient food requires innovative strategies to enhance vegetable productivity and quality while overcoming the limitations of conventional breeding. Vegetables are vital sources of essential nutrients, vitamins, minerals, and bioactive compounds; however...
This research paper explores the potential of CRISPR-based therapeutic approaches in the diagnosis, treatment, and management of lung cancer. It examines how CRISPR-Cas genome-editing technologies can be used to identify and modify cancer-associated genes, investigate molecular mechanisms of tumor development, and deve...
Primary metabolites and their derivatives often serve as intracellular signals. Inositol pyrophosphates are central regulators of phosphate signaling, but their roles in legume nodulation remain poorly understood. Here, we identify two conserved Vip1 Homolog/Diphosphoinositol Pentakisphosphate Kinase genes, MtVIH1 and...
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
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