gene editing

CRISPR/Cas9-mediated targeted mutagenesis of GmMYB100 to increase isoflavone content in soybean seeds

基于生物网络的动态拓扑优化

This paper explores the application of dynamic topology optimization techniques to biological networks, aiming to enhance drug discovery and gene editing. Biological networks, complex systems of interconnected nodes and edges, are increasingly utilized in various fields. Traditional optimization methods often rely on f...

A national framework for managing dual-use research of concern: integrating biosecurity, public health, and research governance

Dual-use research of concern (DURC)—legitimate life-science research that could be misapplied to cause significant harm—has become an increasingly urgent policy challenge. Advances in synthetic biology, gene editing, and artificial intelligence have expanded both the pace and diffusion of high-risk biological work, whi...

Molecular Scissors With a Search Bar: A Historical Development Review of CRISPR and the Editing of the Genome

This article presents a narrative review of CRISPR and the Editing of the Genome in the context of Biology. The literature on this topic has expanded substantially over recent decades, yet it remains fragmented across subfields, methods, and national research traditions. Drawing on an interpretive synthesis of represen...

Lipopolymer Nanoparticle‐Mediated In Vivo CRISPR‐Cas9 Editing of Mrg15 Restores Mitochondrial Mitophagy to Alleviate Metabolic‐Associated Steatohepatitis

A liver‐targeted lipopolymer nanoparticle‐mediated gene editing platform is developed to enable in vivo disruption of Mrg15 by co‐delivery of Cas9 mRNA and Mrg15 sgRNA to identify Mrg15 as a disease‐relevant epigenetic regulator in MASH and highlight liver‐directed P64H LPNP/CRISPR delivery as a promising non‐viral str...

Insights into fodder quality enhancement in sorghum through genetic and molecular approaches

Forage sorghum (Sorghum bicolor L. Moench), a climate-resilient, drought-tolerant fodder crop with high adaptability and biomass potential, plays a significant role in addressing global livestock feed and fodder demands. However, its complex quantitative quality traits, such as crude protein, fibre fractions, crude fat...

Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN): integrating epidemiological insights with diagnostic and therapeutic progress

Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a progressive, fatal multisystem disorder characterized by significant genotypic and geographic heterogeneity. Despite recent therapeutic breakthroughs, overlapping clinical features frequently lead to misdiagnosis and delayed intervention....

Targeting TaNSUN2 provides a potential route to combine antiviral resistance with improved productivity in wheat

Research on crop disease has shifted from a single pathogen-host framework toward a multifactorial host-microbiota-environment framework. This transition, captured by the pathobiome concept, redirects attention from individual pathogens to the broader biological networks that condition disease establishment, progressio...

Deciphering abiotic stress resilience in crop plants through multiomics insights and CRISPR Cas9 mediated genome editing

Abiotic factors, such as drought, salt, severe temperatures, and heavy metal toxicity, persistently threaten global agricultural production, contributing to an estimated 40–70% of yield losses in primary food crops globally. Drought diminishes yields by as much as 50% in rice, 42% in soybean, 40% in maize, 21% in wheat...

Advances in Sexual and Asexual Propagation of Toxicodendron vernicifluum: Mechanisms, Technical Bottlenecks, and Industrialized Breeding Perspectives

Toxicodendron vernicifluum is an economically unique lacquer-producing tree en-demic to East Asia; propagation bottlenecks severely restrict elite clone industrializa-tion. This review systematically synthesizes 20 years of domestic and international lit-erature on seed propagation, root cutting, stem cutting, grafting...

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This paper introduces a novel system for personalized gene editing based on dynamic gene expression modulation, leveraging biological information to tailor gene expression to individual characteristics and environmental factors. Traditional gene editing methods primarily focus on modifying genes, while this system aims...

Dual-gRNA CRISPR/Cas9 Deletion of CsDMR6 in Sweet Orange Supported by Improved In Vitro Regeneration

Huanglongbing (HLB), caused by Candidatus Liberibacter spp., remains the most destructive disease affecting citrus worldwide. To support host-directed genome-editing strategies aimed at reducing susceptibility, we optimized key regeneration steps in Citrus sinensis and validated a dual-gRNA CRISPR/Cas9 approach targeti...