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1,701 papers
This review dissects the differential regulatory mechanisms of ICD-mediated immune memory in CNS tumors versus non-tumor diseases and aims to elucidate the molecular switches that govern the transition of this immune program from a beneficial, compensatory state to a pathological, detrimental phenotype.
The convergence of fungal systems biology with the principles of circular bioeconomy is illustrated and the technological, economic, and regulatory bottlenecks which need to be overcome are pointed out to fully realise the potential of fungi as the biofactories of the future for the sustainable production of energy and...
An Evaluation Agent, middleware that combines Natural Language Inference factual verification, a five-signal poison detector with relevance-weighted aggregation, and a Trust Index is proposed, which reliably blocks instruction injection of unsafe advice while contradiction and subtle semantic weakening remain hard.
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Lipid nanoparticles (LNPs) are promising non-viral vectors for central nervous system (CNS) gene therapy, but effective delivery is limited by the blood-brain barrier and cell-type specificity. Here, we combined intracranial delivery with high-throughput, cluster-based screening and machine learning to identify LNP for...
Dar, S. (2026). CRISPR-Based Gene Editing for Inherited Cardiomyopathies: A Scientific Medical Analysis and Translational Framework. DOI: https://doi.org/10.5281/zenodo.22132605. Affiliations: Director, Medical Wing, MKET Canada; Medical Legal Editor, CLRJ Toronto. Summary In this comprehensive scientific analysis, Dr....
Dar, S. (2026). CRISPR-Based Gene Editing for Inherited Cardiomyopathies: A Scientific Medical Analysis and Translational Framework. DOI: https://doi.org/10.5281/zenodo.22132605. Affiliations: Director, Medical Wing, MKET Canada; Medical Legal Editor, CLRJ Toronto. Summary In this comprehensive scientific analysis, Dr....
In Bacteria and Archaea, mobile genetic elements (MGEs) are extremely diverse in terms of size, structure and mobilization mechanism, ranging from minimal non-autonomous sequences (<100 bp) to complex elements (>100,000 bp) capable of mobilizing many passenger genes. MGEs drive genome evolution and horizontal gene tran...
Fusarium oxysporum is a significant threat to agriculture and One Health, requiring advanced molecular tools for functional genomic analyses and biological control agent development. Existing gene-editing methods are hampered by costly protoplast preparation protocols and by CRISPR-Cas9 limitations, such as restricted...
Rather than treating MNs as a universal replacement for systemic delivery, this review position them as a route-specific platform whose clinical value will depend on rational cargodevice matching, standardized potency testing, and validation in translational models.
A unified theoretical framework formalised by the conceptual equation A + B = 1, where A represents human biological inheritance and B represents dynamic cultural systems is introduced, which establishes a rigorous guardrail against both biological determinism and radical cultural blank-slate models.
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
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Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
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