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1,774 papers
A unified theoretical framework formalised by the conceptual equation A + B = 1, where A represents human biological inheritance and B represents dynamic cultural systems is introduced, which establishes a rigorous guardrail against both biological determinism and radical cultural blank-slate models.
Abstract Gene editing technologies have evolved significantly over the past few decades, revolutionising biomedical research and therapeutics. Initially, restriction enzymes provided researchers with basic tools for deoxyribonucleic acid (DNA) manipulation. However, the advent of engineered nucleases, such as zinc fing...
Induced pluripotent stem cell-derived chimeric antigen receptor natural killer (iPSC-CAR-NK) cells are an evolving off-the-shelf cellular immunotherapy platform with potential for scalable manufacturing, product standardization, and multiplex engineering.This review summarizes recent progress in clinical-grade manufact...
Supporting data for the manuscript: Chaudhari et al., Synthesis cost is a hidden driver of convergent amino acid composition in plastid ribosomal proteins. List of contents:Data S1 Sequence alignments of all surveyed plastid and nuclear genes in Orobanchaceae, Geraniaceae, Fabaceae, and Caryophyllaceae. These genes inc...
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The Bacillus pumilus 3-19 strain exhibits increased secretion of various hydrolases, including proteases, and is a promising plant growth-promoting (PGP) agent, and a deletion mutant of B. pumilus 3-19 with an inactivated mprBp gene was obtained.
It is shown that the RAD23a regulates differential growth, salt response and Pi uptake in rice in a domain-specific manner supporting the moonlighting roles of RAD23a in salt tolerance and phosphorus-dependent shoot growth.
P phenotypic, physiological, and transcriptomic analyses were integrated to elucidate the drought adaptation mechanisms of a gamma-ray-induced mutant wheat line, PL6, alongside its wild-type parent, PL1, demonstrating an effective analytical framework for selection of high-confidence transcripts.
Supporting data for the manuscript: Chaudhari et al., Synthesis cost is a hidden driver of convergent amino acid composition in plastid ribosomal proteins. List of contents:Data S1 Sequence alignments of all surveyed plastid and nuclear genes in Orobanchaceae, Geraniaceae, Fabaceae, and Caryophyllaceae. These genes inc...
Genetic Disorders: Molecular Mechanisms, Diagnostic Evolution, Precision Therapeutics and Future Directions Description Genetic Disorders: Molecular Mechanisms, Diagnostic Evolution, Precision Therapeutics and Future Directions is a comprehensive narrative review examining the current understanding and rapidly evolving...
The article traces the trend of directed differentiation technologies evolving from two-dimensional culture to three-dimensional organoids and details their practical applications in diseases such as stroke, Alzheimer's disease, and spinal cord injury—particularly in spinal cord injury models, where transplanted cells...
The knockout and re-expression platform provides a useful gene editing tool for primary T cells in fundamental research and immunotherapy development and can be used to generate gene-edited primary T cells for in vivo studies, such as the quantification of anti-tumor responses.
The results demonstrate that the AI-designed OpenCRISPR-1 system is a highly active and versatile nuclease for dicot genome engineering, offering a powerful, commercially unencumbered tool to accelerate global crop trait improvement.
Host Sowbhagya Suresh shares some of the latest news and cutting-edge research from across Microsoft—from understanding the challenges facing coding agents to uncovering how people use AI at work and improving extended-range weather forecasting. The post Microsoft Research Focus – Edition #97 appeared first on Microsoft Research.
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
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Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
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