CRISPR-Cas technology has revolutionized functional genomics, and gene therapy by enabling precise and programmable manipulation of the genome. Early CRISPR-Cas nucleases relied on the generation of double-strand breaks (DSBs) to disrupt genes or introduce exogenous DNA. More recently, the development of base editors a...
Jenny Gao· University of Massachusetts...· 0 citations
This is the first public release of the analysis code accompanying the manuscript "Differential expression and machine-learning classification of Parkinson's disease using AMP-PD RNA-seq data" (Hu R, Dong X, et al.). Overview Analysis pipeline for RNA-seq–based differential expression (DE) and machine-learning (ML) cla...
TheDongLab· Zenodo (CERN European Organi...· 0 citations
The articles collected in this Research Topic highlight the growing integration of genomics and microbial ecology in advancing plant disease management and soil health. Together, they demonstrate how molecular approaches can reveal the mechanisms that shape microbial communities, uncover the genetic basis of pathogen v...
Setu Bazie Tagele, Assefa Sintayehu Kassa, Shimeles Tilahun et al.· Frontiers in Microbiology· 0 citations
This is the first public release of the analysis code accompanying the manuscript "Differential expression and machine-learning classification of Parkinson's disease using AMP-PD RNA-seq data" (Hu R, Dong X, et al.). Overview Analysis pipeline for RNA-seq–based differential expression (DE) and machine-learning (ML) cla...
TheDongLab· Zenodo (CERN European Organi...· 0 citations
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Genetic Disorders: Molecular Mechanisms, Diagnostic Evolution, Precision Therapeutics and Future Directions Description Genetic Disorders: Molecular Mechanisms, Diagnostic Evolution, Precision Therapeutics and Future Directions is a comprehensive narrative review examining the current understanding and rapidly evolving...
Dr.Zeeshan Qaiser· Zenodo (CERN European Organi...· 0 citations
Current evidence on the immuno-epigenetic regulation of neuroinflammation after ICH is synthesized, with emphasis on cell-specific mechanisms, temporal dynamics, and immune–vascular interactions.
Yi-Fan Li, Wei Jiang, Fang Zhong et al.· Frontiers in Immunology· 0 citations
Liver failure (LF) represents a severe clinical syndrome associated with rapid deterioration of hepatic function, high mortality, and limited therapeutic options. Despite extensive research efforts, the complex pathogenesis of LF remains incompletely understood, and effective therapeutic strategies remain limited. Anim...
Lu Tian, Jiale Zhang, Dongyue Jiao et al.· Stem Cell Research & Therapy· 0 citations
Agriculture stands at a critical crossroads. Escalating challenges from climate change, population growth, resource constraints, and complex biotic and abiotic stresses demand crop improvement strategies that are faster, more precise, and more sustainable than conventional breeding alone. Genetically modified (GM) and...
Moslem Bahmankar, Maryam Salehi, Mohammad Reza Naghavi et al.· Frontiers in Sustainable Foo...· 0 citations
Gene expression analysis revealed that certain genes, uniquely edited during the mating stage of MvSup, tend to be upregulated in the haploid stage but downregulated during mating, and vice versa, while the a2 haploid strain of MI had fewer editing sites compared to other haploid strains.
Shikhi Baruri, Nasara Shamsudeen, Alycia C. R. Lackey et al.· Journal of Fungi· 0 citations
The second-crop corn has become one of the main agricultural production systems in Brazil, with the state of Paraná being one of the largest national producers of this crop. The expansion of the soybean-corn system has significantly contributed to increased grain production and the strengthening of animal protein produ...
Helio Souza· Agronomy Science and Biotech...· 0 citations
CRISPR is biology's most improbable technology: a bacterial adaptive immune system, recognized only gradually from odd repeated sequences in microbial genomes, became within a decade the universal tool of genome editing---Cas9's programmable double-strand cuts, the Cas12 and Cas13 families' extensions, and prime editin...
Zen Revista, 10 BIOLOGY· Zenodo (CERN European Organi...· 0 citations
Description Thalassemia as a Genetic Disorder: From β-Globin Mutation to Precision Prevention and Gene-Based Therapy is an evidence-informed international review that provides a comprehensive overview of thalassemia as an inherited genetic disorder, with particular emphasis on the molecular basis of disease, β-globin g...
Dr.Zeeshan Qaiser· Zenodo (CERN European Organi...· 0 citations
Host Sowbhagya Suresh shares some of the latest news and cutting-edge research from across Microsoft—from understanding the challenges facing coding agents to uncovering how people use AI at work and improving extended-range weather forecasting. The post Microsoft Research Focus – Edition #97 appeared first on Microsoft Research.
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
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