gene editing

Can host genetics transform the sustainable control of tropical theileriosis? Insights from the Tick-Theileria interface.

The evidence indicates that host genetics will not replace existing control but could reduce reliance on acaricides and chemotherapy, and the evidence indicates that host genetics will not replace existing control but could reduce reliance on acaricides and chemotherapy.

Gene editing of alveolar organoids reveals AT2 dysfunction due to endosomal SFTPC accumulation.

Endosomal dysfunction and polarity loss are established as drivers of SFTPC-I73T-mediated epithelial injury and mechanisms that may underlie AT2 dysfunction in disease more broadly are highlighted.

Global genetic modifiers of fetal hemoglobin in sickle cell disease: Systematic review and meta-analysis.

Evidence on genetic determinants of Hb F and quantified effects of key variants through meta-analysis is synthesized, supporting genotype-guided therapeutic, and genome-editing strategies.

CRISPR gene therapy: a review

Clinical applicability is limited by issues such off-target effects, PAM sequence restrictions, DNA damage-induced toxicity, and immunological responses to Cas proteins, despite its wide therapeutic potential, but improvements in delivery methods and high-fidelity Cas9 variations are being addressed.

Intranasal CRISPR lipid nanoparticles targeting MAPK9 attenuate neuroinflammation after traumatic brain injury

It is demonstrated that intranasal delivery of Iba-1-targeted CRISPR-LNPs enables effective MAPK9 modulation in Iba-1 + myeloid cells within the injured brain and attenuates acute neuroinflammation following TBI.

Eimeria in chickens: Recent advances in host-pathogen interactions, molecular insights, and control strategies.

This review systematically synthesizes key advances over the past decade concerning host-Eimeria interactions, molecular regulatory mechanisms, and novel control strategies, while contextualizing these findings with earlier seminal discoveries.

Gene Editing Therapy Developer Scribe Therapeutics Closes $155.5M IPO.

Genome-wide Identification of CXE Gene Family in Soybean and Functional Characterization of GmCXE31 in Lipid Biosynthesis and Salt Tolerance.

This study elucidates the multifaceted roles of GmCXE31 in coordinating soybean salt tolerance, lipid metabolism and agronomic traits, providing theoretical and genetic resources for salt-tolerant and high-quality soybean molecular breeding.

Programmable Domestication: CRISPR, Pan‐Genomics and System Level Engineering for Next‐Generation Crops

ABSTRACT Global agriculture is increasingly challenged by climate instability, genetic erosion, emerging pathogens and rising food demands, exposing the limitations of conventional breeding and traditional domestication strategies. Recent advances in CRISPR‐based genome editing, pangenomic, synthetic biology, artificia...

Immune cell development from human pluripotent stem cells.

This review summarizes research with a focus on clinical translation of iPSC-derived immune cells, as well as highlights continued challenges and prospects of this field.

Mitochondrial DNA A3243G variant-associated MELAS: Recent advances in clinical trials, therapeutic interventions, and disease-modifying strategies.

The therapeutic landscape for MELAS is evolving from symptomatic care toward mechanism-based disease modification, led by taurine as the first regulatory-approved disease-modifying therapy and complemented by late-stage small molecules and mitochondrial genome-editing technologies.

Beyond Mixed Utilization: Fractionation, Functional Divergence, and Precision Applications of Soybean 7S and 11S Globulins.

Soybean β-conglycinin (7S) and glycinin (11S) differ markedly in their structure, physicochemical properties, and bioactivity; however, industrial practice still treats them as a mixed ingredient, obscuring their differentiated functional potential. This review critically evaluates fractionation technologies through th...