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1,774 papers
This research introduces a novel strategy to augment casein expression in ruminants, providing a significant theoretical foundation and technical support for the precision breeding of high-casein dairy cows and goats.
Competition with adenosine deaminase acting on RNA 1 (ADAR1), melanoma differentiation-associated protein 5 (MDA5), double-stranded RNA-dependent protein kinase (PKR), the cyclic guanosine monophosphate–adenosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS–STING) pathway, and oth...
This article systematically reviews the component design, structural engineering, preparation technologies, clinical applications, and future development directions of LNPs, aiming to provide theoretical support and practical guidance for vector development in the era of precision medicine.
Evidence is provided suggesting that StFKF1 influences the timing of flowering and tuber initiation, as well as the expression patterns of key regulatory genes, under long-day conditions, thereby contributing to a theoretical foundation for understanding developmental transitions in this specific environmental context.
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A new protoplast-based platform enables transient transformation and proof-of-concept CRISPR/Cas12a-mediated genome editing in European beech, a key but recalcitrant forest tree species.
A potential combination between gene therapy approaches and existing modulators to improve treatment eligibility, safety, and efficacy for cystic fibrosis patients is discussed.
A review of studies in which the creation of a CRISPR-Cas9 animal model has been used to find genetic drivers and develop therapies across 4 CVD domains shows the vast range of gene editing applications and the value of models that parallel human genetic pathophysiology for specific disease processes.
It is demonstrated that viperin plays a central role in coordinating antiviral responses in rainbow trout macrophages and is essential for proper activation of classical IFN–ISG pathways.
Preliminary evidence indicates that targeted editing of OsASY offers a promising strategy to reduce grain Cd content without adversely affecting major agronomic traits or yield, highlighting its potential as a molecular target for breeding low-Cd-accumulating rice varieties.
By explaining how a single amino acid change produces a hypomorphic PIEZO2 allele, the findings broaden the clinical spectrum of PIEZO2 disorders and offer structural insight into mechanotransduction.
Overall, the existing findings support TAAR1 as a therapeutic target for treatment of substance use disorders, however, translating these findings into effective human pharmacotherapies requires navigating ligand-specific effects and pharmacokinetic demands and defining the role of human TAAR1 genetic diversity in ther...
This paper focuses on the heterologous expression of functional genes via transgenic technology and explores the potential of gene editing technologies for heavy metal remediation, thereby offering a reference for future environmental remediation efforts and the development of related processes.
Host Sowbhagya Suresh shares some of the latest news and cutting-edge research from across Microsoft—from understanding the challenges facing coding agents to uncovering how people use AI at work and improving extended-range weather forecasting. The post Microsoft Research Focus – Edition #97 appeared first on Microsoft Research.
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Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
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