gene editing

Pioneering the next generation therapies in Parkinson's disease

Gene dosage effect and reduced core fucosylation in B lymphocytes of FUT8 heterozygous mice

Core fucosylation (alpha1,6-fucosylation) of N-glycans, catalyzed solely by fucosyltransferase 8 (FUT8), plays important roles in development, immunity, and antibody effector functions. Here we report the generation of Fut8 floxed mice using a CRISPR/Cas9-based Extreme Genome Editing (EGE) system, in which loxP sites f...

A naturally evolved mutation in cavefish mc3r reshapes energy homeostasis across development in a nutrient-limited environment

Food availability in natural habitats is often unpredictable and drives the selection of adaptive strategies in organisms to survive food scarcity. However, the genetic and molecular mechanisms that enable animals to survive under such nutritional extremes are poorly understood. Naturally adapted organisms therefore pr...

Introduction: Metals in Health and Environment

Metals occupy a unique and often paradoxical position at the interface between human health and the environment. Essential metals such as iron, zinc, copper, magnesium, and molybdenum are indispensable for numerous biological processes, yet their deficiency or excess can lead to serious health consequences. In contrast...

Biohacking Our Way to Health and Transhumanism

Biohacking emerged as a grassroots movement that seeks to democratize biology, biotechnology, and healthcare. Initially known as garage biology, biohacking developed from the convergence of synthetic biology, citizen and open-source science, and advances in biotechnology. What began as amateur experimentation in home l...

Maternal obesity imprints methylation marks in oocytes to drive intergenerational metabolic dysfunction.

Wheat Rust Diseases: Global Impact, Integrated Disease Management, and Emerging Biotechnological Innovations for Sustainable Crop Protection

Simple Summary Wheat feeds a large share of the world’s people, yet every growing season it faces a persistent enemy: a group of fungal diseases known as rusts. These fungi travel long distances on the wind, multiply quickly, and keep changing in ways that allow them to defeat the protection bred into wheat plants. Whe...

Programming primary human T cells to deliver gene editing machinery

Clinical applications of gene editors including CRISPR-Cas9 are limited by the cell-type specificity and tissue penetrance of current in vivo delivery options. Cell-mediated gene editor delivery could overcome these obstacles. To date, systems utilizing immortalized cell lines have demonstrated gene editor delivery in...

Current Evidence on Gene-Based and Epigenetic Therapeutic, Diagnostic, and Prognostic Strategies in Epithelial-Derived Carcinomas: A Scoping Review

Background: Epithelial-derived carcinomas exhibit genomic instability due to genetic mutation and epigenetic dysregulation. Mechanisms such as DNA methylation, histone modifications, and noncoding RNA regulation may lead to tumor progression, immune evasion, and treatment resistance. Presently, gene-based and epigeneti...

Complete assembly of Onobrychis viciifolia mitochondrial genome reveals evolutionary dynamics

Pushing the Boundaries of Knowledge in Alpha-1 Antitrypsin Deficiency.

Cutting-edge preclinical and translational developments with potential to redefine AATD management and move toward curative approaches are highlighted, highlighting cutting-edge preclinical and translational developments with potential to redefine AATD management.

Male reproductive genes influencing mating and fertility: enhancing the sterile insect technique and genetic control of Diptera pests.

A synthesis of male reproductive genes and regulatory pathways in Diptera according to the reproductive processes they control and the failure modes caused by their disruption can inform target prioritization, strain maintenance, and quality control of irradiated males, thereby enhancing the refinement of SIT and relat...