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gene editing

1,595 papers

#natural language process... Open access Aug 2026

The Synthetic Consensus Trap: Correlated AI Errors, Verification Overload, and the Mathematics of Institutional Epistemic Cascades

Institutions are beginning to use multiple large language models, AI agents, automated reviewers, and human overseers as if agreement among them were independent corroboration. That assumption can fail. This paper develops the Synthetic Consensus Cascade (SCC) framework, a multidisciplinary mathematical model linking c...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Aug 2026

Does ChatGPT Undermine Human Epistemic Authority? A Multi-Dimensional Analysis of Artificial Intelligence's Challenge to Knowledge Systems

The emergence of ChatGPT and similar large language models has precipitated fundamental questions about the nature and distribution of epistemic authority in contemporary knowledge systems. This comprehensive analysis examines whether ChatGPT undermines human epistemic authority through a multi-dimensional theoretical...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Aug 2026

Does ChatGPT Undermine Human Epistemic Authority? A Multi-Dimensional Analysis of Artificial Intelligence's Challenge to Knowledge Systems

The emergence of ChatGPT and similar large language models has precipitated fundamental questions about the nature and distribution of epistemic authority in contemporary knowledge systems. This comprehensive analysis examines whether ChatGPT undermines human epistemic authority through a multi-dimensional theoretical...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Jul 2026

Radical Empathy as a Moral Imperative in the 21st Century: The Empathic Imperative Thesis

This thesis examines whether radical empathy constitutes a moral imperative in the 21st century, presenting a novel theoretical framework termed the Empathic Imperative Thesis (EIT). Through comprehensive analysis of philosophical foundations, empirical evidence, and contemporary global challenges, this work argues tha...

Kwan Hong TAN · 0 citations
#artificial intelligence Book Open access Jul 2026

Radical Empathy as a Moral Imperative in the 21st Century: The Empathic Imperative Thesis

This thesis examines whether radical empathy constitutes a moral imperative in the 21st century, presenting a novel theoretical framework termed the Empathic Imperative Thesis (EIT). Through comprehensive analysis of philosophical foundations, empirical evidence, and contemporary global challenges, this work argues tha...

Kwan Hong TAN · 0 citations
#quantum computing Open access Jul 2026

Joint State-Law Fixed Points in Quantum Theory: Recursive Dynamics, Bifurcations, and Renormalization-Group Deformations

This article develops a joint state-law fixed-point method for self-consistent quantum models. A physical model is represented by a density operator and a finite-dimensional vector of effective law parameters; admissible dynamics consist of a state-update channel and a law-update map. A recursive solution is their join...

Kwan Hong TAN · 0 citations
#quantum computing Open access Jul 2026

Joint State-Law Fixed Points in Quantum Theory: Recursive Dynamics, Bifurcations, and Renormalization-Group Deformations

This article develops a joint state-law fixed-point method for self-consistent quantum models. A physical model is represented by a density operator and a finite-dimensional vector of effective law parameters; admissible dynamics consist of a state-update channel and a law-update map. A recursive solution is their join...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Jul 2026

Beyond Participatory Explanation: Ontological Reflexivity Theory as a Resolution to the Consciousness Emergence Problem

David Cota’s evaluation of the author’s “participatory explanation” approach to consciousness reveals fundamental conceptual problems that plague contemporary consciousness studies. Cota identifies a critical conflation between reason as a symbolic-operational function, and consciousness as a phenomenal-experiential fi...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Jul 2026

Beyond Participatory Explanation: Ontological Reflexivity Theory as a Resolution to the Consciousness Emergence Problem

David Cota’s evaluation of the author’s “participatory explanation” approach to consciousness reveals fundamental conceptual problems that plague contemporary consciousness studies. Cota identifies a critical conflation between reason as a symbolic-operational function, and consciousness as a phenomenal-experiential fi...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Aug 2026

The Autonomy Externality: A Welfare-Economic Model of Agentic Artificial Intelligence, Correlated Failure, and Optimal Assurance Policy

Agentic artificial intelligence is shifting automation from prediction and recommendation toward autonomous execution. This transition creates an economic externality that is not captured by conventional firm-level investment models. A firm receives much of the productivity benefit from delegating decisions to an artif...

Kwan-Hong Tan · 1 citation
#gene editing Review Open access Sep 2026

Analysis of SpCas9 on- and off-target effects in high efficiency multiplex editing in Arabidopsis

RNA-guided nucleases (RGNs), such as Cas9 from Streptococcus pyogenes (SpCas9), are widely used for plant genome editing. Previous surveys for off-targeting, the modification of unintended targets with similarity to the intended target, indicate high specificity of SpCas9 in plant cells. However, off-targeting has not...

J. Stuttmann, J. Keilwagen, Philipe Ortet et al. · 0 citations
#gene editing Open access Sep 2026

Grass Carp Autophagy-Related Gene 5 Shows Inflammatory Regulation Function During Grass Carp Reovirus Infection

Grass carp (Ctenopharyngodon idella) aquaculture faces significant challenges due to grass carp hemorrhagic disease, which is instigated by the grass carp reovirus (GCRV). A major contributor to the high mortality rates associated with this disease is an excessive inflammatory response. Autophagy contributes to host di...

Xin-Yi Cao, Bei-Bei Qin, Rui-Zhong Wei et al. · 0 citations

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Microsoft Research Blog Oct 15, 2026

Proof-based general-purpose computing with Magnetar

Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.

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