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gene editing

1,648 papers

#artificial intelligence Open access Jul 2026

Beyond Participatory Explanation: Ontological Reflexivity Theory as a Resolution to the Consciousness Emergence Problem

David Cota’s evaluation of the author’s “participatory explanation” approach to consciousness reveals fundamental conceptual problems that plague contemporary consciousness studies. Cota identifies a critical conflation between reason as a symbolic-operational function, and consciousness as a phenomenal-experiential fi...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Jul 2026

Beyond Participatory Explanation: Ontological Reflexivity Theory as a Resolution to the Consciousness Emergence Problem

David Cota’s evaluation of the author’s “participatory explanation” approach to consciousness reveals fundamental conceptual problems that plague contemporary consciousness studies. Cota identifies a critical conflation between reason as a symbolic-operational function, and consciousness as a phenomenal-experiential fi...

Kwan Hong TAN · 0 citations
#artificial intelligence Open access Aug 2026

The Autonomy Externality: A Welfare-Economic Model of Agentic Artificial Intelligence, Correlated Failure, and Optimal Assurance Policy

Agentic artificial intelligence is shifting automation from prediction and recommendation toward autonomous execution. This transition creates an economic externality that is not captured by conventional firm-level investment models. A firm receives much of the productivity benefit from delegating decisions to an artif...

Kwan-Hong Tan · 1 citation
#gene editing Review Open access Sep 2026

Analysis of SpCas9 on- and off-target effects in high efficiency multiplex editing in Arabidopsis

RNA-guided nucleases (RGNs), such as Cas9 from Streptococcus pyogenes (SpCas9), are widely used for plant genome editing. Previous surveys for off-targeting, the modification of unintended targets with similarity to the intended target, indicate high specificity of SpCas9 in plant cells. However, off-targeting has not...

J. Stuttmann, J. Keilwagen, Philipe Ortet et al. · 0 citations
#gene editing Open access Sep 2026

Grass Carp Autophagy-Related Gene 5 Shows Inflammatory Regulation Function During Grass Carp Reovirus Infection

Grass carp (Ctenopharyngodon idella) aquaculture faces significant challenges due to grass carp hemorrhagic disease, which is instigated by the grass carp reovirus (GCRV). A major contributor to the high mortality rates associated with this disease is an excessive inflammatory response. Autophagy contributes to host di...

Xin-Yi Cao, Bei-Bei Qin, Rui-Zhong Wei et al. · 0 citations
#gene editing Dataset Open access Sep 2026

Doc2LoRA idea genes: reproduction code and archived intermediates for "Doc2LoRA Provides Decodable Representations of Scientific Ideas"

The reproduction workflow and the archived intermediate results for the paper. Everything needed to rebuild the manuscript's tables is here: the code is a snapshot of the trimmed reproduction repository, and the bundles hold the computed intermediates, so a reader does not have to re-derive them. Reproducing from the r...

Chand Sahil Mansuri, Joel Zachariah, Sadamori Kojaku · 0 citations
#gene editing Open access Sep 2026

PS1-1. Introducing Gene-Editing Semen for the Slick Mutation to Mitigate Fescue Toxicosis in Angus Cattle.

Tall fescue pastures support 40% of U.S. cow-calf herds, but fescue toxicosis causes heat stress and reduces animal performance and welfare. A mutation in the prolactin receptor (Slick mutation) gives cattle a sleek hair and reduces body temperature. This mutation does not occur naturally in Angus cattle, but can be...

Lucas C. S. Branco, Juliet E. Henning, Raquel F. Oliveira et al. · 0 citations
#gene editing Sep 2026

Study of the genus Rosehip (Rosa) using molecular biological methods

This study presents a molecular genetic analysis of a rosehip sample using DNA barcoding and phylogenetic approaches. The aim of the research was species identification based on comparative analysis of nucleotide sequences of nuclear and chloroplast marker genes ITS, matK, rbcL, and trn. Genomic DNA was extracted from...

E. Andronov, T. Darbaeva, S. Bakiyev et al. · 0 citations
#gene editing Open access Sep 2026

Targeted Mutations in d-ldh and budA Differentially Affect Adaptive Traits and Fermented Milk Quality in Companilactobacillus crustorum MN047

This study examined how targeted mutations in two pyruvate-associated genes, d-ldh and budA, affected adaptive phenotypes and fermented milk quality in Companilactobacillus crustorum MN047. Premature stop codons were introduced into d-ldh and budA by CRISPR-assisted base editing and verified by Sanger sequencing. The r...

Jia Li, Pan-Pan Wang, Zi-Wen Qu et al. · 0 citations
#gene editing Review Open access Sep 2026

Pathophysiology and Comprehensive Pharmacological Management of ATTR Cardiac Amyloidosis: Knowledge Gaps, Ongoing Clinical Trials, and Future Research Directions

Cardiac amyloidosis is an increasingly recognized cause of heart failure in the setting of progressive restrictive cardiomyopathy, particularly among older adults, males, and individuals of African descent, with remarkable advances in the therapeutic landscape, but substantial knowledge gaps persist.

Sareen Bains, Harry Atwal, Ashbir Sidhu et al. · 0 citations
#gene editing Open access Sep 2026

PS10-4. Effect of Mutating Porcine CYP17A1 for Altering Pregnenolone Metabolism to Control Boar Taint.

Using a well-defined cell culture system to identify targets for producing gene edited pigs without boar taint could not only improve pork production but also give insight into a highly complex cytochrome P450 system.

Alyssa Lini, C. Bone, E. J. Squires · 0 citations
#gene editing Dataset Open access Sep 2026

Replication Data for: Rice leaf structural adjustment to sustain photosynthetic traits under drought and produce more grain: Evidence from field studies of the 3K indica panel

Understanding plant traits that contribute to maintenance of physiological activities under drought is crucial for sustainable rice production. Leaf morphological characters together with UAV-based HTP measurements of canopy temperature (CT) and NDVI, leaf water potential (ψLeaf), photosynthetic traits including A, gs...

Chatterjee Jolly, Dionora Mary Jacqueline, Laza Ma Rebecca et al. · 0 citations

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Microsoft Research Blog Oct 15, 2026

Proof-based general-purpose computing with Magnetar

Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.

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