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1,648 papers
Further advancements in CRISPR technology such as high-fidelity CRISPR and new systems Cas12 and Cas13 which increases efficiency of editing and opens more opportunities are discussed which increases efficiency of editing and opens more opportunities.
A testable model wherein environmental triggers and host hormone balance converge temperature-regulated virulence gene expression to govern the endophyte-to-necrotroph transition is proposed.
A distinct "Asian way" of xenotransplantation is proposed that integrates scientific excellence with cultural diversity and regional solidarity to shape the future of transplantation medicine.
Functional analysis evaluating the effectiveness of gene editing revealed that prime editing of the F508del mutation in the CFTR gene—using the pegRNA4 combined with the PE2-NG variant—restores CFTR channel conductance, comparable to triple therapy with CFTR modulators.
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Background/Objectives: OsMRS2-6 is a member of the MRS2/MGT family, but its relationship with chloroplast status and growth and development in rice remains incompletely understood. Methods: In this study, we generated OsMRS2-6 knockout and overexpression lines and combined transient subcellular localization, chloroplas...
The findings support a hypothesis that porcine adipocyte beiging and CD137-related cross-species interactions may be relevant to xenograft immunometabolism; direct experimental validation in xenotransplantation models is required.
A T/Brachyury promoter to CRISPR interference targeting CTNNB1, which encodes the canonical Wnt signaling mediator β-catenin, provides a proof of concept for combining a developmental promoter with a programmable intracellular regulator and identifies a strategy for separating circuit integration from unintended target...
Soil contamination by heavy metals, petroleum hydrocarbons, and excessive agrochemical inputs, coupled with declining soil fertility, poses a major threat to sustainable cereal and fruit production and global food security. This review synthesizes evidence from peer-reviewed studies published between 2000 and 2026 to...
An evidence-based framework provides a roadmap for moving from observed tolerance mechanisms toward experimentally validated molecular targets and their deployment in climate-resilient pigeonpea breeding.
These findings establish BE scanning as a scalable approach for network-level chemical-genetic interaction mapping, revealing new mechanistic insights into one of the most studied oncogenic pathways.
The mechanisms and current uses of gene upregulation strategies are reviewed and their advantages and limitations are critically evaluated as therapies for inherited cardiomyopathies.
Biosecurity screening of synthetic DNA orders is a key defense against malicious actors and careless enthusiasts producing dangerous pathogens or toxins. It is important to evaluate biosecurity screening tools for potential vulnerabilities and to work responsibly with providers to ensure that vulnerabilities can be pat...
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
General Science
GPT-Lab
· gpt-lab.eu
Oct 8, 2026
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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