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1,648 papers
What's Changed ZFIN-10433: fetch the PANTHER classifications over HTTPS by @cmpich in https://github.com/ZFIN/zfin/pull/1964 ZFIN-10389: Update journals with ISSNs by @cmpich in https://github.com/ZFIN/zfin/pull/1963 ZFIN-10344 Follow-up: Add parameters to make the switchover easier by @rtaylorzfin in https://github.co...
The reproduction workflow and the archived intermediate results for the paper. Everything needed to rebuild the manuscript's tables is here: the code is a snapshot of the trimmed reproduction repository, and the bundles hold the computed intermediates, so a reader does not have to re-derive them. Reproducing from the r...
Genome editing in avian systems has largely relied on plasmid-based CRISPR systems and antibiotic selection to achieve successful editing. However, plasmid delivery can result in prolonged nuclease expression and potential unintended DNA integration. In addition, selection-based enrichment may mask the intrinsic geno...
This Zenodo deposit contains a publicly available description of the Dataset: Title: "iSCORE-PD: NGS genotyping and zygosity testing of isogenic hESC clones". Description: Targeted DNA sequencing data for the iSCORE-PD isogenic hESC clone collection, encompassing three complementary analyses: (1) NGS genotyping of 53 m...
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Antisense oligonucleotides and genome editing can restore transcript fidelity by preventing cryptic exons inclusion in STMN2 and UNC13A, thereby stabilizing neuronal function and improving the lifespan and quality of life of patients with ALS.
This Zenodo deposit contains a publicly available description of the Dataset: Title: "iSCORE-PD: NGS genotyping and zygosity testing of isogenic hESC clones". Description: Targeted DNA sequencing data for the iSCORE-PD isogenic hESC clone collection, encompassing three complementary analyses: (1) NGS genotyping of 53 m...
An effective method for eliminating HLA class I expression in HEK293T cells via simultaneous CRISPR/Cas9 editing of the HLA‑A, HLA‑B, and HLA‑C genes using a single guide RNA is described.
This study engineer compact photoswitchable Cas12f (psCas12f) proteins that are co-deliverable with their single guide RNA (sgRNA) in a single AAV particle, enabling precise spatiotemporal control in vivo.
A unifying innate-sensing architecture for nucleic-acid therapeutics is defined and it is established that reactogenicity is not required for effective vaccination or gene delivery, enabling a broadly applicable strategy to widen the safety window of mRNA medicines, viral vectors, and in vivo genome editing.
This review introduces 'translational checkpoints' as a synthesized working framework for overcoming resistance by targeting RNA-binding proteins (RBPs) that govern rapid protein synthesis in tumour and immune cells and establishes a four-subtype diagnostic stratification system and five actionable therapeutic strategi...
DOPA decarboxylase (DDC) is a key enzyme that connects melanin production and innate immunity in insects, yet its regulatory network in major lepidopteran pests remains poorly understood. We combined CRISPR/Cas9 gene editing with multi-omics analysis to explore DDC's role in immune responses in the invasive pest Spodop...
The ecology- and genomics-driven evolution of this economically important virus and strategies targeting streak resistance in maize are discussed, and a five-cardinal agenda for future research covering layered surveillance-supported host resistance, evolutionary surveillance, agro-ecological alignment of breeding, esc...
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
General Science
GPT-Lab
· gpt-lab.eu
Oct 8, 2026
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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