Persistent infection with high-risk human papillomaviruses (hrHPVs) is a primary driver of cervical carcinogenesis, with the viral oncogenes E6 and E7 playing pivotal roles. Conventional nuclease-based gene-editing strategies are limited by genome-wide off-target effects and genomic perturbations associated with double...
Yue Kang, Yi-Fan Wu, Bing-Ting Bao et al.· Molecular Therapy· 0 citations
A comprehensive genome-wide analysis identified 19 serine protease-like DEG family proteins in potato, revealing their structural diversity, domain architecture, and regulatory potential and highlighting the functional versatility of DEG proteases in potato development and stress adaptation.
Abhilash Reddy Gangula, Payal Mavadiya, Krishnakant D. Tandel et al.· Potato Research· 0 citations
This work presents a variant-agnostic approach to rescue haploinsufficiency by mapping and rationally redesigning the MYBPC3 promoter and identifies synergistic sequence edits that drive robust increases in MYBPC3 expression.
Aaron Renberg, S. Coppersmith, Owen Merritt et al.· bioRxiv· 0 citations
It is demonstrated that a synthetic circular intermediate, or “starmid”, is sufficient for recombinase-dependent integration into the host genome and that circularisation enhances expression of the starship-encoded tyrosine recombinase through juxtaposition of 3′ and 5′ terminal sequences.
Allira Baericke, Vanta J. Jameson, Andrew S. Urquhart· bioRxiv· 0 citations
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This review presents the stem cell technologies applied in tissue engineering, regenerative medicine, or organ transplantation. It describes how certain types of stem cells are different in terms of their characteristics, the methods of their culture isolation, gene editing, and three-dimensional organoid construction....
Charan Sai Lanka· International Journal of Sci...· 0 citations
Cancer remains a major cause of global mortality, while late-stage diagnosis and therapeutic resistance highlight the need for individualized strategies. Nanotheranostics has emerged as a promising paradigm by integrating cancer diagnosis and treatment within multifunctional nanosystems. However, most current approache...
Lida Dastanpour, Mohammad Aref Bagherzadeh, Sanaz Rezaeian et al.· Figshare· 0 citations
This review examines the historical development of CRISPR technology from its initial discovery as a bacterial immune mechanism to its transformation into a revolutionary genome editing tool. The narrative traces the key scientific milestones that led to the adaptation of CRISPR-Cas9 as a precise molecular scissor capa...
Zen Revista, 10 BIOLOGY· Zenodo (CERN European Organi...· 0 citations
This review systematically synthesizes the liver's multifaceted roles in teleost salinity adaptation, including glucolipid metabolic reprogramming, osmosensory signaling, cytoskeleal remodeling, and hormonal coordination.
You-Di Tang, Zhuo-Ling Liu, Liu-Ye Huang et al.· Reviews in Aquaculture· 0 citations
This review examines the historical development of CRISPR technology from its initial discovery as a bacterial immune mechanism to its transformation into a revolutionary genome editing tool. The narrative traces the key scientific milestones that led to the adaptation of CRISPR-Cas9 as a precise molecular scissor capa...
Zen Revista, 10 BIOLOGY· Zenodo (CERN European Organi...· 0 citations
# Data and code for "Causal screening of the plasma proteome and skin transcriptome in keloid: six candidate loci and the limits of Mendelian randomisation for target nomination" Version v1.0. This archive accompanies the manuscript above (Li Zhifeng, Li Jingyu; Zhejiang Provincial People's Hospital). It contains the a...
Zhifeng Li, Li Jingyu· Zenodo (CERN European Organi...· 0 citations
It is argued that improvements in editing efficiency alone will be insufficient; clinical success will require the simultaneous achievement of tumor‐selective delivery, genomic integrity, and acceptable long‐term safety, and the continued development of novel approaches should be promoted to realize the full potential...
M. Mohiuddin, Md Al Mamun Ahsan· Health Science Reports· 0 citations
The current therapeutic landscape is synthesized, pathway-targeted disease modification from etiology-directed genetic strategies are explicitly distinguished, and key translational barriers for gene-based approaches are highlighted, including target-tissue delivery to the growth-plate, dose control and durability acro...
E. Kondrateva, Svetlana A. Smirnikhina· International Journal of Mol...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
