This article offers a historical development review of CRISPR-Cas systems, the adaptive immune architecture of bacteria and archaea that became, within a single decade, the most consequential genome editing technology in the history of biology. The review reconstructs the field's development across five phases: the obs...
Zen Revista, 10 BIOLOGY· Zenodo (CERN European Organi...· 0 citations
The synthesis highlights the importance of combining established breeding methods with emerging genomic and biotechnological approaches while conserving wild accessions and landraces.
M. L. Nath, G. Seeja, S. Sreekumar et al.· Journal of Advances in Biolo...· 0 citations
CAF-directed stromal priming as a strategy to enhance chemoimmunotherapy and warrant evaluation in randomized studies with integrated biomarker analyses are supported.
V. S. Kalluri, B. Bockorny, Evelio Perea Borobio et al.· Cancer Research· 0 citations
A residue-resolved prioritization platform for covalent cancer drug discovery. CanProTarget integrates cancer gene dependencies, small-molecule covalent ligand engagement measured by chemoproteomics, and base-editing evidence for individual cysteines, keeping each layer at the resolution it is measured at.
John-Paul Ong, Daniel Martins, Jean B. Bertoldo· Zenodo (CERN European Organi...· 0 citations
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Findings identify SFRP2 as a key regulator of PDAC progression and support the development of SFRP2-targeted therapies as a novel treatment strategy for pancreatic cancer.
Olivia Sweatt, Lillian Hsu, Lety Reyes Angeles et al.· Cancer Research· 0 citations
This review systematically summarizes the key improvements and evolutionary progress in the prime editor design and its updated delivery systems, with a particular focus on innovative modifications that have successfully overcome technical barriers.
Shu-Ran Zhang, Leong Chang, Ya-Min Kong et al.· Current Gene Therapy· 0 citations
Using CRISPR-Cas9 gene editing in human pluripotent stem cells, HOPX is identified as an important regulator of oRG-like cell maintenance and the neurogenic-gliogenic balance, providing insight into the molecular programs governing human neural progenitor expansion.
Xiao-Xue Dong, Wendy W. Y. Choi, Mai Ahmed et al.· Stem Cell Reports· 0 citations
UnZipro is presented, an efficient, scalable, and generalizable framework for zero-shot, in silico protein evolution, that integrates a compact, pre-trained inverse folding model with meta-learning to derive family-specific fitness landscapes.
Zhao-Hui Qin, Sanzeng Zhao, Zhao-Long Deng et al.· Molecules and Cells· 1 citation
This study provides high-quality mitogenome assemblies for P. calleryana and P. betulifolia, revealing coexisting structural variations and highly conserved sequences, and thereby offers a significant genetic resource for the Rosaceae family that will facilitate further investigations into the molecular diversity and g...
Huan Zhang, Hong-Liang Ji, Yu-Tong Chi et al.· Frontiers in Plant Science· 0 citations
It is demonstrated that co-inactivation of HSD17B11 followed by PAC selection can be used to rapidly identify efficient guide RNAs targeting a gene of interest and to readily isolate clones inactivated for one or multiple genes.
Bastien Dumais, Madeleine Bossaert, Patrick Seigneur et al.· bioRxiv· 0 citations
A Python script that draws tRNA cloverleaf secondary-structure diagrams from tRNAscan-SE output. Every structure is drawn on the same fixed template: acceptor stem up, D-arm left, anticodon arm down and T-arm right, with the anticodon highlighted and a 3′-CCA appended. Base pairs, stem and loop lengths, and anticodon p...
Tianhui Hina Zhou· Zenodo (CERN European Organi...· 0 citations
Although recent studies suggest the dysbiosis of gut microbiome in multiple system atrophy, as a contributor to dysfunctional intestinal barrier, new methods, including fecal RT-QuIC, smell testing, microbiota replacement, and gene-editing therapies, offer more promising evidence for diagnosis and disease-modifying the...
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
