Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behavior and impaired social interactions. Recent reports from human postmortem brain samples of ASD show transcriptome-wide dysregulations, including changes in differential gene expression and alternative splicing. An importan...
Tourmaline v2.1.0 This release adds two new taxonomy features — the REVAMP classify method by Sean McAllister and optional Krona plots — and has a major overhaul of the documentation. Existing configuration files continue to work unchanged. No parameters were renamed or removed. Still requires QIIME 2 2024.10 in an env...
Luke Thompson, Katherine Silliman, Luke Thompson et al.· Zenodo (CERN European Organi...· 0 citations
A roadmap for developing crops with low metal accumulation and high stress tolerance through precision breeding and gene editing is provided, to provide a roadmap for developing crops with low metal accumulation and high stress tolerance through precision breeding and gene editing.
Liu-Liu Wu, Li-Fan Cao, Jun-Yan Sun et al.· Plant, Cell and Environment· 0 citations
Two novel knock-in mouse lines using CRISPR-Cas9-mediated genome editing provide faithful tools for investigating the cellular and molecular mechanisms regulating dentinogenesis and osteocyte biology, as well as for studying dental and alveolar bone tissues, with potential applications in craniofacial biology.
T.-H. Wang, M. Yang, Y. Liu et al.· Journal of dentistry researc...· 0 citations
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Genome engineering via CRISPR/Cas9 has been widely applied in biological research and developing gene therapies. However, genome editing flexibility is strongly constrained by the position and quality of guide RNAs relative to the intended edit: desired edit sites are frequently positioned far from efficient protospace...
Chenfu Zhao, Yan Hong Cao, Kirill A. Martemyanov· bioRxiv (Cold Spring Harbor...· 0 citations
Clinically, PBDs are encompassed within the Zellweger spectrum disorders (ZSDs) and are encompassed within the Zellweger spectrum disorders (ZSDs) respectively.
Yong Hwan Kim, Doo Sin Jo, Ae-kyeong Kim et al.· Signal Transduction and Targ...· 0 citations
Genetic engineering of the myostatin gene in dairy cattle represents a promising approach for sex-specific beef performance enhancement. A possible genetic strategy to enhance beef traits in male dairy calves uses the introduction of a myostatin knockout on the Y chromosome. Using CRISPR/Cas9, this sex-specific edit wo...
Fernando Mata, Joaquim Cerqueira, Gustavo Paixão et al.· 0 citations
Editorial on the Research TopicTrends and perspectives for the use of crop wild relatives in crop breeding, volume II Crop wild relatives (CWRs) are crucial assets for agrobiodiversity, sustainable agriculture, and food security, offering vital genetic traits such as pest resistance, resource efficiency, and extreme we...
CUREIPES was developed and is the first molecular tool that enables human Apobec1-dependent C-to-U RNA editing-inducible protein expression, which can be used to counteract pathological alteration of C-to-U RNA editing through cell-autonomous expression of editing-regulatory proteins, or of any other protein of interes...
Magnus Harnau, Yulia Novykova, Jacqueline Weicht et al.· Nucleic Acids Research· 0 citations
This review systematically summarizes the comparative advantages, application prospects, and industrialization challenges of microalgal protein as an alternative protein source and provides an integrated framework for the low-cost, scalable, and sustainable production of microalgal alternative protein.
This review summarizes the structural, evolutionary, and functional characteristics of WRKY transcription factors involved in flowering regulation in Brassica species and demonstrates substantial expansion of WRKY gene families through genome triplication and polyploidization.
M. Raihan, Itezaz Younas, Shuo-Wei Su et al.· Plant Science· 0 citations
A glial cell model deficient in the NAGLU enzyme via CRISPR/Cas9 editing system in the U-87MG cell line exhibited typical traits for MPS IIIB, including decreased enzyme activity and mitochondrial mass, as well as increased lysosomal mass, neutral lipids, total glycosaminoglycans, and total reactive oxygen species.
Katherin D. Niño-Traslaviña, Diego A. Súarez, Oscar F. Sánchez et al.· Neurochemical Research· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
