gene editing

Gene editing to improve stress resilience in wheat

Water deficit, salinity, and low-temperature stresses negatively affect wheat production worldwide, underscoring the need to develop stress-tolerant wheat varieties. This can be achieved by modifying the stress response mechanisms and regulations in plants. The recent DNA-editing approach, CRISPR/Cas editing, can accur...

Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cells

CanProTarget

A residue-resolved prioritization platform for covalent cancer drug discovery. CanProTarget integrates cancer gene dependencies, small-molecule covalent ligand engagement measured by chemoproteomics, and base-editing evidence for individual cysteines, keeping each layer at the resolution it is measured at.

Therapeutic reprogramming of natural killer cells for solid tumors: expanding frontiers into rare and ultra-rare malignancies

Progress in NK cell therapy across solid tumors provides a framework for extending increasingly adaptable and scalable immunotherapeutic platforms to rare and ultra-rare malignancies, with the potential to expand treatment opportunities for patient populations that have historically had limited therapeutic options.

Protein language models predict artemisinin partial resistance and prioritize genetic modifiers in Plasmodium falciparum

Translational Cardiology in Genetic Cardiomyopathies

Translational cardiology applied to genetic cardiomyopathies is a rapidly evolving field that bridges molecular research and clinical practice through a “bench-to-bedside and back” paradigm. Hereditary cardiomyopathies, once classified primarily based on clinical phenotype, are now increasingly understood at the molecu...

Biotechnological Advances and Multi‐Omics Insights for Fruit Quality, Postharvest Biology, and Genetic Improvement in Litchi ( Litchi chinensis Sonn.)

This review critically synthesizes current progress in litchi biotechnology, encompassing chromosome‐scale genome assembly, molecular marker systems, SNP resources, and functional genomics studies that have identified major regulatory genes and transcriptional networks associated with flowering, pigmentation, senescenc...

Bactomics HybAs v8.4-lite

This release is a major workflow upgrade from the legacy 8.4-lite Snakefile to a batch-capable, provenance-aware, benchmarked, validation-enabled, report-ready HybAs implementation. The new workflow preserves the core hybrid assembly logic while substantially improving execution control, reproducibility, taxonomic deci...

Bactomics HybAs v8.4-lite

This release is a major workflow upgrade from the legacy 8.4-lite Snakefile to a batch-capable, provenance-aware, benchmarked, validation-enabled, report-ready HybAs implementation. The new workflow preserves the core hybrid assembly logic while substantially improving execution control, reproducibility, taxonomic deci...

Morphological and biochemical evaluation of tolerance to water deficit identifies SlCLE9 as a novel regulator of drought stress

A screening to evaluate the responses to water deficit before the flowering stage uncovered new potential trait donors for breeding against drought stress and describes a novel role for SlCLE9 in drought tolerance in tomato.

Arrhythmogenic Cardiomyopathy

Arrhythmogenic cardiomyopathy (ACM) is an inherited myocardial disease characterized by progressive fibro-fatty replacement of the ventricular myocardium, predisposing to ventricular arrhthmias, heart failure, and sudden cardiac death. Historically described as arrhythmogenic right ventricular cardiomyopathy (ARVC), AC...

CanProTarget

A residue-resolved prioritization platform for covalent cancer drug discovery. CanProTarget integrates cancer gene dependencies, small-molecule covalent ligand engagement measured by chemoproteomics, and base-editing evidence for individual cysteines, keeping each layer at the resolution it is measured at.