Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization in vivo. To define the molecular architecture of a model aECM we generated a toolkit of 105 fluorescently tagged aECM componen...
J. M. Ragle, Murugesan Pooranachithra, Guinevere A. Ashley et al.· PLoS Biology· 0 citations
Poison exons are highly conserved exons whose inclusion creates premature termination codons and triggers nonsense-mediated decay (NMD) of the mature transcript. Despite their important role in post-transcriptional regulation, poison exons remain poorly annotated due to the lack of systematic transcriptome-wide approac...
Paolo Pigini, Huilin Xu, Yan Ji et al.· Genome biology· 0 citations
Retinitis pigmentosa (RP) is the most common inherited retinal dystrophy and remains largely untreatable. This review summarizes RP pathogenesis and critically appraises emerging therapeutic strategies, including gene augmentation, gene editing, RNA-based therapies, gene-agnostic and neuroprotective approaches, stem-ce...
Nicolas Tuli, Moath Baeshen, Mohamed Echbicheb et al.· Vision· 0 citations
As classic examples of adaptive evolution, insect mimicry and masquerade have been studied extensively for more than a century. Both phenomena protect insects from predators and are widely observed in nature. Previous research on phenotypic, genetic, phylogenetic, and behavioral aspects has laid a solid foundation for...
Yu-Bo Zhang, Wei Zhang· Annual Review of Entomology· 0 citations
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Friedreich's ataxia (FRDA) is a multisystemic neurodegenerative disorder caused by GAA repeat expansion in intron 1 of frataxin (FXN), resulting in FXN deficiency and mitochondrial dysfunction. Current therapies do not correct the underlying genetic defect. Here, we demonstrate that ex vivo CRISPR/Cas9 excision of the...
Anusha Sivakumar, Alexis N. Corl, Keneth Jordan Muñoz et al.· Journal of Clinical Investig...· 1 citation
Abstract Late-stage oxidative remodeling of tropolone cores underpins the remarkable scaffold diversity in fungal meroterpenoid biosynthesis. However, the mechanistic basis by which a single enzymatic catalyst diverts a common substrate toward carbon-excising ring contraction versus carbon-retentive skeletal rearrangem...
Ziang Chen, Jiawang Liu, Songlin Bai et al.· Journal of the American Chem...· 0 citations
Phenylketonuria (PKU) is a monogenic metabolic disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene, the most common of which is c.1222C>T (p.R408W). Current treatment options, including dietary restriction and enzyme substitution, can be effective but are often challenging for patients to maintain...
S. Yazinski, S. Canali, Yang Xu et al.· bioRxiv· 0 citations
Gene editing of five key negative regulatory genes,
GS3
,
OsBADH2
,
Xa13
,
Bsr‐d1
and
OsSULTR3;6
, generated an elite ideal‐type rice variety
mk‐10
, which exhibits a longer grain shape, enhanced tolerance to heat and alkali stress, increased 2AP content, and simultaneous resistance to
Xoo
, rice blas...
Jiang-Min Xu, Jian-Min Li, Yi-Lin Luo et al.· Plant, Cell and Environment· 0 citations
This article analyses modern, biologically targeted approaches to the treatment of breast cancer in middle-aged women. The main focus is on determining the pathomorphological and molecular characteristics of the tumour, the role of immunotherapy, particularly in triple-negative breast cancer, the current level of clini...
Dadamukhamedova Khalida Erkinovna, Begimqulov Mirjalol Yashin ugli, Kuvondikova Zulfizar Jasurbek qizi· International Journal of Int...· 0 citations
Progressive familial intrahepatic cholestasis (PFIC) encompasses genetically heterogeneous disorders affecting bile transport, membrane organisation, epithelial polarity and bile-acid signalling. Current medical and surgical treatments can improve symptoms and disease course in selected patients, but substantial unmet...
Ziyu Jiang, S. Tamir Rashid, Paul Gissen et al.· Preprints.org· 0 citations
Pathogenic variants in NONO are clinically linked to congenital heart disease (CHD), but in vivo mechanisms and gene-targeted interventions remain poorly explored. Using CRISPR/Cas9 gene editing and morpholino silencing, we established knockout (KO) and knockdown (KD) zebrafish models to study nono in cardiogenesis. Ad...
The 2018 “gene-edited babies” incident involving He Jiankui elicited widespread global condemnation, and he was subsequently convicted of and sentenced for illegal medical practice. Although several years have passed, impulses and initiatives aimed at advancing the clinical application of human germline genome editing...
Dan Yang· Humanities and Social Scienc...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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