GHKL ATPases share a unique Bergerat ATP-binding fold and regulate diverse biological processes through ATP-dependent conformational changes. An early step of ATP hydrolysis in this family has been attributed to a single highly conserved glutamate residue proposed to function as the general base. However, mutations of...
Transport of macromolecules between the nucleus and cytoplasm requires a gradient of the small GTPase, Ran. Ran:GTP marks the nucleus because Ran activity requires a cytoplasmic GTPase activating protein (RanGAP) for GTP hydrolysis. As expected for such central and essential cellular machinery, both Ran and RanGAP are...
Pravin S. Dewangan, Michael L. Reese· Proceedings of the National...· 0 citations
Background. Type 2 diabetes mellitus (T2DM) is diagnosed at decompensation thresholds — fasting plasma glucose (FPG) ≥126 mg/dL or HbA1c ≥6.5% — that typically declare disease only after substantial β-cell loss. Normoglycemic offspring of parents with T2DM carry several-fold lifetime risk yet receive no structured surv...
Alireza Zare banadkouki· Zenodo (CERN European Organi...· 0 citations
Background. Type 2 diabetes mellitus (T2DM) is diagnosed at decompensation thresholds — fasting plasma glucose (FPG) ≥126 mg/dL or HbA1c ≥6.5% — that typically declare disease only after substantial β-cell loss. Normoglycemic offspring of parents with T2DM carry several-fold lifetime risk yet receive no structured surv...
Alireza Zare banadkouki· Zenodo (CERN European Organi...· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
Model code, digitised source data and figure scripts for a forward model of deposit formation in granular corneal dystrophy type 2 (TGFBI R124H), treated as precipitation of a slightly supersaturated protein in a curved, partly non-renewing tissue rather than as a protein-folding disease. The work has no experimental d...
Sejun Kim· Zenodo (CERN European Organi...· 0 citations
Understanding protein folding is crucial for protein sciences. The conformational spaces and energy landscapes of cold (unfolded) protein states, as well as the associated transitions, are hardly explored. Furthermore, it is not known how structure relates to the cooperativity of cold transitions, if cold and heat unfo...
Edward H. Snell, Brian Kuhlman, Lakshmanane Premkumar et al.· UNC Libraries· 0 citations
In summary, loss of qseB disrupts the QseB/QseC system, which affects stress response, metabolism, and cell structure, providing clues for understanding the pathogenic mechanisms of G. parasuis.
Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...
Zeyuan Ma· Zenodo (CERN European Organi...· 0 citations
The collective data uncover the critical role of D229 in toxin folding and structural dynamics, which in turn impacts toxin potency through effects on the efficiency of PDI-driven toxin disassembly.
F. Kersten, Natalia Mojica, Albert Serrano et al.· ACS Omega· 0 citations
Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...
Zeyuan Ma· Zenodo (CERN European Organi...· 0 citations
Toxic protein aggregates can accumulate in the cytosol and within organelles of cells when protein quality control machinery fails. Here, we systematically analyzed the consequences of protein aggregation in mitochondria by targeting aggregation-prone proteins to the mitochondrial matrix in Saccharomyces cerevisiae and...
Hauke Holthusen· Universitätsbibliothek der L...· 0 citations
It is demonstrated that loss of membrane-bound catechol-O-methyltransferase (MB-COMT), a key degrader of DA in the brain, disrupts cellular metal handling and redox-regulatory pathways and triggers widespread protein misfolding in schizophrenia and Parkinson’s disease.
S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al.· Proceedings of the National...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
