A comprehensive RNA-sequencing analysis of postmortem nucleus accumbens tissue from individuals with OUD and matched controls provides an integrated view of candidate genetic and transcriptomic alterations in OUD and identifies lncRNA-centered regulatory networks and candidate variant-bearing genes as hypothesis-genera...
R. Chakraborty, C. Guda, Avinash M. Veerappa· Frontiers in Cellular Neuros...· 0 citations
Overview This paper addresses the P versus NP problem by proposing a fundamental epistemological and geometric rupture. Rather than treating the "combinatorial explosion" characteristic of NP problems as an intrinsic physical or mathematical barrier, this work demonstrates that it is an artifact of measuring a multi-di...
Cláudio Vicente da Silva· Zenodo (CERN European Organi...· 0 citations
A preclinical quantitative systems pharmacology model of α-PD-1, α-CTLA-4, and their combination in syngeneic mouse models provides a quantitative scaffold for guiding preclinical-to-clinical evaluation of checkpoint-combination strategies.
Yu Zhang, Hanwen Wang, Natsuki Furukawa et al.· ACS Pharmacology & Trans...· 0 citations
Background: Euryale ferox Salisb. seed (Euryales Semen) is a traditional Chinese medicine whose therapeutic application is modulated by wheat bran stir-frying, a process that enhances its effects on tonifying the spleen and kidney. The molecular mechanisms and alterations in bioactive components underlying this process...
Pan-Pan Li, Yao-Jia Zou, Ying-Hao Mao et al.· Metabolites· 0 citations
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Source data underlying the figures and supplementary data of this manuscript.- figshare_Figure_data.xlsx: Numerical source data for Figures 1, 3, 4, 5, 6, and 7 (19 sheets, one per panel).- figshare_Data Set S1.xlsx: Differential protein expression results (log2 fold change, p-value) for three pairwise comparisons amon...
Takashi Saito, Momoko Kobayashi (721582), Zhengkuan Sun et al.· Figshare· 0 citations
Grasspea (Lathyrus sativus L.) is a versatile, climate-resilient legume valued for its nutritional richness and low input requirements. However, the presence of the neurotoxin β-N-oxalyl-L-α, β-diaminopropionic acid (β-ODAP) has limited its popularity. The present study aimed to identify promising low-ODAP grasspea gen...
Sen Subhajit, Datta Jhuma, Roy Soumyayan et al.· Plant Science Today· 0 citations
Bronchiectasis is increasingly recognised as a chronic airway disease, but is often diagnosed only after irreversible structural abnormalities have developed. To characterize plasma molecular patterns preceding the first recorded bronchiectasis diagnosis, we analysed baseline plasma proteomics in the UK Biobank Pharma...
Yihan Shi, Dong Weng, Yuqing Wang et al.· Respiratory Research· 0 citations
These models could support triage and prioritization of patients already under evaluation for suspected MM, particularly where access to specialized testing is delayed; use in lower-prevalence, first-contact settings would require recalibration and dedicated validation.
B. Erdoğdu, Duygu Gül, Berrak Itır Aylı et al.· Diagnostics· 0 citations
A condition-dependent condensate state for CC1NTD is defined and a novel mechanism for the formation and maintenance of stress-associated cellulose synthase compartments driven by LLPS of the disordered regions of CSC and accessory proteins is proposed.
Viswanathan Gurumoorthy, Qiu Zhang, W. Leite et al.· bioRxiv· 0 citations
SLFN5 is a DNA- and RNA-binding protein with endonuclease activity on specific RNA substrates, which determines the role of SLFN5 as a tumor suppressor.
Jun-Ying Ou, Jin-Yu Yang, Meng-Ni Luo et al.· Health and Metabolism· 0 citations
Tideglusib is established as a mechanistic chemical probe for NatA, NatA is revealed as a previously unrecognized molecular target for a promiscuous clinical-stage investigational compound, and a conceptual framework for exploiting catalysis-dependent adduct formation as a new strategy for acetyltransferase inhibitor d...
Youchao Deng, Zhuo-Jun Luo, Sarah M. Gardner et al.· ACS Chemical Biology· 0 citations
Background/Objectives: This study investigated the potential of nanostructured lipid carriers (NLCs) to improve the in vitro skin delivery and retention of bioactive compounds derived from Bombyx mori silk cocoon. Furthermore, an NLC-based facial serum was developed and clinically evaluated for its efficacy and safety....
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
