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2,530 papers
LEV and JNJ-42153605 applied briefly after TBI offer a potent polypharmacy approach, at least in the preclinical animal model, to tackle the later tau aggregation and neurodegeneration that follows from TBI neurotrauma.
Testing the ability of common large language models to consider design principles to generate de novo proteins that bind metals and lipophilic small molecules without copying existing sequences highlights the utility of LLMs in making protein design more comprehensible and accessible to users without sophisticated desi...
How protein structural differences regulate the performance of protein-polysaccharide nanoparticles is revealed and theoretical and technical insights into the precise design and practical application of delivery systems for LYC and other lipophilic bioactive compounds are provided.
This study provides the first structural basis for pUG- fold RNA recognition by a protein and illustrates how cryo-EM and AI-based methods for protein and RNA structure prediction synergize to inform the mechanism of RNA-mediated regulation of DNMT1.
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Among KTRs with T2DM or PTDM, SGLT2i use was associated with a lower combined risk of graft loss, all-cause mortality, or doubling of serum creatinine, without an increased incidence of adverse events.
Secretory vesicle transport from the Golgi to the cell membrane involves kinesin and myosin Va motors on the vesicle surface cooperatively navigating their shared cargo through numerous actin-microtubule (MT) intersections. How the track on which the cargo exits the intersection is selected so that vesicles are deliver...
A generic numbering scheme for TMEM16 scramblases (GNS-TMEM16), modeled on the Ballesteros & Weinstein system established for class A G protein-coupled receptors, is introduced, bringing to light the advantages of corresponding residues identification in different TMEM16 proteins and show that the mammalian scramblase...
A regulatory role is identified for the conserved, intrinsically disordered C-terminal tails of GroEL, one of the best-studied ATP-dependent chaperones, to reveal how the conformational properties of an intrinsically disordered element can be exploited to optimize the energetic efficiency and functional timing of a lar...
This work describes a label-free colorimetric immunoassay that initially integrates rolling circle amplification (RCA) with Tyndall effect (TE) characteristics of nucleic acid colloids. Using only a laser pointer and a smartphone, it achieves instrument-free protein quantification with 13-fold higher sensitivity than t...
It is found that reverse folding algorithms are unable to energetically minimize evolutionary conserved frustration at specific residues, even when detrimental to overall structural stability, and it is proposed that these frustration hotspots act as architectural spandrels, inherent physical constraints of the fold th...
A dual pattern of genomic adaptation in Ethiopian zebu cattle is revealed and candidate loci for future validation and climate-resilient livestock breeding are provided.
Rosmarinic acid (RA) significantly alleviates DSS-induced colitis by repairing the damaged colonic mucus barrier and reversing gut microbiota dysbiosis. However, it remains unclear whether the gut microbiota is required for this protective effect. To address this, pseudo-germ-free mouse models and fecal microbiota tran...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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