Category
2,550 papers
A substantial number of deleterious variants involved glycine substitutions, which are likely to affect protein flexibility, folding, and intermolecular interactions, potentially impairing the structural integrity of the glomerular basement membrane.
Established genomic and population-level evidence support a Likely Pathogenic, loss-of-function classification for the TTN p.Arg3936Ter variant, which introduces a premature termination codon predicted to generate a truncated titin protein of 3,935 amino acids and is predicted to escape nonsense-mediated decay.
Dynamical Topology Optimization (DTO) provides a framework for optimizing complex network topologies by iteratively refining connections based on emergent properties. This paper introduces a novel algorithm, termed 'Adaptive Topology Evolution', which integrates reinforcement learning and graph theory to achieve automa...
Motivation: Convergent evolution produces enzymes with different folds but identical catalytic mechanisms, yet no method reliably detects shared catalytic sites across non-homologous proteins. Dedicated catalytic site tools achieve recall below 4%, and general-purpose aligners sacrifice local catalytic geometry for glo...
Reach audiences
Advertise in front of researchers, engineers, and readers.
Motivation: Convergent evolution produces enzymes with different folds but identical catalytic mechanisms, yet no method reliably detects shared catalytic sites across non-homologous proteins. Dedicated catalytic site tools achieve recall below 4%, and general-purpose aligners sacrifice local catalytic geometry for glo...
The immunomodulatory effect of E. menziesii safely regulates macrophage behavior, IL-1β and IL-6 release and promotes scratch area reduction and could be linked to the presence of sulfate polysaccharides and mannitol.
ESMCHalo is a frozen protein-sequence predictor that combines ESMC-600M layer-36 canonical mean representations with five compact student heads trained using leakage-free out-of-fold knowledge distillation. The release provides frozen inference code, model checkpoints, calibration, a fixed threshold, verification utili...
[Post-submission revision] - 2026-09 Following a desk rejection from JBSD (concerns: depth of analysis, novelty, rationale clarity), the following additional analyses and fixes were made. Fixed Protein topology (Leu289 truncation): topology/topol_Protein_chain_A.itp was found to be missing 11 atoms (CD1/CD2 side chain...
Preconditioning the skin with non-ablative laser energy represents a promising strategy to enhance tissue repair, yet its biological mechanisms remain incompletely defined. This study investigated whether pre-injury stimulation using a 755-nm picosecond Alexandrite laser (PSAL) equipped with a diffractive lens array (D...
[Post-submission revision] - 2026-09 Following a desk rejection from JBSD (concerns: depth of analysis, novelty, rationale clarity), the following additional analyses and fixes were made. Fixed Protein topology (Leu289 truncation): topology/topol_Protein_chain_A.itp was found to be missing 11 atoms (CD1/CD2 side chain...
An investigation into the structural, electronic and reactive properties of a substituted piperidine scaffold were conducted using density functional theory (DFT) at the B3LYP/6-31 G(d) level of theory. Molecular geometry optimization established a stable equilibrium structure. Frontier molecular orbital (FMO) analysis...
ESMCHalo is a frozen protein-sequence predictor that combines ESMC-600M layer-36 canonical mean representations with five compact student heads trained using leakage-free out-of-fold knowledge distillation. The release provides frozen inference code, model checkpoints, calibration, a fixed threshold, verification utili...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
