Category
2,550 papers
The study of complex systems often faces challenges in characterizing their inherent dynamics and identifying emergent patterns. Traditional chaos theory metrics, while valuable, often fail to fully capture the nuanced interplay of non-linear interactions driving these patterns. This paper introduces the Dynamical Chao...
The study of complex systems often faces challenges in characterizing their inherent dynamics and identifying emergent patterns. Traditional chaos theory metrics, while valuable, often fail to fully capture the nuanced interplay of non-linear interactions driving these patterns. This paper introduces the Dynamical Chao...
Overall, plant-derived peptides show directionally consistent bioactivity in Caco-2 models, but the evidence rarely identifies the responsible molecular species or confirms physiological attainability, and future work should prioritise metabolic characterisation, exposure-justified concentrations, and multi-omics appro...
Edaphic antibiotic resistance genes (ARGs) have garnered worldwide concern, yet mechanisms by which specific microbial taxa drive ARG variation under anthropogenic stress remain unclear. Here we show how opportunistic and sensitive taxa contribute to ARG propagation in soil microcosms exposed to conventional (polyethyl...
Reach audiences
Advertise in front of researchers, engineers, and readers.
This paper investigates the statistical topology of complex structures, focusing on the identification of underlying patterns and prediction of emergent behavior within datasets exhibiting inherent statistical properties. We propose a novel method, the "Resonance Field" concept, to quantify these properties and establi...
ABSTRACT Bromodomain and extra‐terminal (BET) proteins are validated therapeutic targets for cancer, but clinical translation of pan‐BET inhibitors is limited by dose‐limiting toxicities from non‐selective inhibition of BD1/BD2 domains. Herein, we report the first‐ever domain‐selective covalent inhibitor, named i p AE1...
Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding and insertion of outer membrane proteins (OMPs). The Escherichia coli Bam complex...
Mechanisms supporting microbial survival under lethal selenite [Se(IV)] concentrations during bioremediation remain elusive. This study employed integrated multi-omics to analyze Lactiplantibacillus plantarum BSe (LPB) under extreme Se(IV) stress. LPB achieved 76.32% removal at 100 mM Se(IV), but this high efficiency c...
The potential molecular mechanisms by which Hedyotis diffusa alleviates lung injury from multiple perspectives are explored, providing experimental evidence and theoretical insights for further mechanistic studies and clinical drug development.
Aerial parts of native perennials Satureja montana and Teucrium montanum were spectrophotometrically compared on the levels of antioxidant potential, phenolics, soluble sugars and proteins, suggesting a greater potential for phenolic-associated bioactivity.
Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic resistance. Central to this is the β-barrel assembly machine (Bam) complex and its associated chaperones, which are responsible for transport, folding and insertion of outer membrane proteins (OMPs). The Escherichia coli Bam complex...
We introduce a solid-phase synthesis platform for the rapid, modular, and scalable synthesis of the synthetic metallophore KO-NH2, which is readily recognized by bacterial siderophore transporters, but has optimized affinity for Ga3+ over Fe3+. Four synthetic protochelin (PC) analogues, KK-COOH, KO-NH2, KO-COOH, and OK...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
