protein folding

Title: Temporal Topology Optimization for Biological Systems

Temporal Topology Optimization (TTO) presents a novel approach to biological system optimization, moving beyond static parameterization to model the dynamic evolution of topological states. This paper introduces a system leveraging network theory and evolutionary dynamics to predict emergent behaviors within biological...

Chloramphenicol stress triggers oxidative adaptation in Acinetobacter baumannii ATCC19606 devoid of RND efflux pumps AdeAB or AdeIJ

The findings reveal efflux pump-specific and strain-specific adaptations to antibiotic stress, positioning CraA as a major determinant of chloramphenicol resistance, while RND transporters such as AdeABC and AdeIJK may also be associated with broader stress adaptation processes, including redox and metal homeostasis, i...

Title: Algorithmic Complexity of Parallel Simulations of Complex Systems

This paper investigates the algorithmic complexity of parallel simulations of complex systems, aiming to develop a novel algorithm that significantly reduces computational costs while maintaining accuracy. Complex systems, such as protein folding and climate modeling, demand substantial computational resources. Existin...

Title: Dynamic Evolutionary Algorithm for Protein Folding with Topology Preservation

Protein folding is a fundamental biological process, and achieving accurate and stable folding is critical for protein function. Current methods often struggle to preserve the intricate network of interactions within the protein structure, leading to misfolded proteins and disease. This paper introduces a novel Dynamic...

Analytical validation of a multiplexed peptide microarray for multi-antigen Epstein–Barr virus serological profiling across diverse clinical specimens

The platform as an analytically characterized, peptide-level EBV serology tool for translational research is supported, indicating that platform-level seropositivity reflects EBV exposure rather than an obvious MS-specific signal.

The Use of Fullerenol as a Seed Treatment to Maintain the Intensity of Physiological and Biochemical Processes of Wheat in Control and Low-Temperature Conditions

It is of utmost importance to investigate the effect of carbon-based nanostructures on plants in order to fully unlock their potential for enhancing productivity and stress tolerance. In this study, a comprehensive assessment of the effect of pre-sowing treatment of wheat seeds with fullerenol (PHF [C60(OH)24], 0.1 mg/...

Systematic In Silico Screening of Nigerian Medicinal Plant Phytoconstituents Against Six Breast Cancer-Associated Proteins

Flexible Catechol-Conjugated Chitosan/Gelatin Bilayer Patches for Topical Hemostasis in Laparoscopic Surgery

This study optimized CHI–C/Geln bilayer patches for laparoscopic surgical application by controlling patch thickness through compression and found that these flexible adhesive patches could serve as topical hemostats that function effectively in laparoscopic surgery.

Rethinking Alzheimer's: Why Neurodegeneration Begins at the Physical Boundary, Not with Protein Plaques

Decades of clinical trials targeting amyloid-beta plaques and tau tangles have yielded minimal therapeutic reversal in Alzheimer’s disease. Recent structural biology demonstrates that by the time macroscopic protein aggregates appear, the neuron’s fundamental information-processing highway—the microtubule lattice—has a...

A Truncated Serpin D1 Variant Regulates Adseverin-Dependent Actin Severing and Is Required for Osteoclastogenesis

Adseverin is a Ca2+-dependent, actin severing protein that promotes fusion of osteoclast precursors in osteoclast formation. Currently it is not understood how actin severing activity is regulated in osteoclastogenesis. Mass spectrometry of adseverin immunoprecipitates from osteoclasts showed that adseverin associated...

Title: Algorithmic Complexity of Parallel Simulations of Complex Systems

This paper investigates the algorithmic complexity of parallel simulations of complex systems, aiming to develop a novel algorithm that significantly reduces computational costs while maintaining accuracy. Complex systems, such as protein folding and climate modeling, demand substantial computational resources. Existin...

Single nucleus RNA sequencing and spatial transcriptomics reveal unique functionalities of gray matter versus white matter oligodendrocytes in aging and Alzheimer’s Disease

This analysis identified a conserved newly formed differentiating (NFOL)/differentiating → lipid remodeling → Stress/ISR-reactive architecture, with a pronounced expansion of the Stress/ISR-reactive compartment and altered transition-associated pathway enrichment in high ADNC WM.