The RF model based on six readily available laboratory parameters accurately predicts 30-day mortality in septic shock patients, however, the findings are limited by the single-center retrospective design and lack of external validation, warranting further multi-center studies to confirm generalizability.
Shan-Bi Chang, Yue-Bang Wang, Zi-Jin Zhang et al.· Frontiers in Microbiology· 0 citations
It is suggested that spatial stiffness heterogeneity, rather than stiffening alone, contributes to predicted curvature localization in skin surrogate bilayers and may provide a mechanics-based readout for evaluating prospective cosmetic interventions.
Yiwen Li, Feng Cao, Qian-Wen Fan et al.· Cosmetics· 0 citations
The first validated liquid chromatography tandem mass spectrometry (LC-MS/MS) bioanalytical method for the quantification of atirmociclib in mouse plasma is reported, validated in compliance with international council for harmonisation-M10 (ICH-M10) guidelines.
Ashwani Gaur, U. Patel, Ashutosh Gavali et al.· Journal of chromatography. B...· 0 citations
The signaling pathways that regulate cellular redox homeostasis, the cellular waste disposal system, ER stress and autophagy are major signaling pathways involved in aSMCs’ responses to uremic serum exposure, which may contribute to the severe arterial-specific clinical symptoms observed in CKD/ESKD patients.
You-You Zheng, Kent A. Lee, U. Uriyanghai et al.· Biomolecules· 0 citations
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Structural prediction and coimmunoprecipitation indicate that the compound variants may be associated with the development of MSS by weakening SIL1-BiP binding, and preliminary functional evidence that the identified variants may affect SIL1 abundance and SIL1-BiP interaction, supporting their relevance to the MSS phen...
Findings support DepPrior as a reproducibility-oriented, hypothesis-generating approach for target nomination for lung adenocarcinoma targets by requiring concordant evidence of CRISPR dependency separability, molecular predictability, and cross-cohort expression/protein reproducibility.
Feng-Fei Zhou, Cheng Wang, Li-Zhi Mo et al.· Frontiers in Pharmacology· 0 citations
Stable constitutive expression of host-derived BiP was associated with prolonged late-stage GLP-1–Fc accumulation in the producer population examined, and these kinetics are compatible with a model in which the timing of ER chaperone supply influences the maintenance of productive output.
R. R. Shaifutdinov, Fedor A. Krukov, Anastasia S. Samok et al.· Bioengineering· 0 citations
Although CSF protein levels did not correlate with proteinuria or perinatal outcomes, spot urine proteinuria is a significant predictor of preeclampsia, FGR, and the need for NICU admission.
A. Erdoğan, Fatih Akkuş, Huriye Ezveci et al.· Genel Tip Dergisi· 0 citations
A5 is developed, a fluorogenic substrate for aldehyde dehydrogenase 2 (ALDH2) that exhibits high isoform selectivity and a >240-fold signal enhancement over the standard NADH assay, and enables quantitative imaging of ALDH2 activity across multiple biological scales.
Rongrong Tao, Yu Chen, Taorui Yang et al.· Journal of the American Chem...· 4 citations
LT16 outperformed existing antiandrogens by fully antagonizing clinical AR mutations and effectively suppressing castration- and enzalutamide-resistant LNCaP cells proliferation in vitro and in vivo, positioning it as a promising and innovative therapeutic for advanced PCa.
Xin Chai, Xinyue Wang, Lvtao Cai et al.· Journal of Medicinal Chemist...· 2 citations
PepBAN is introduced, a deep learning framework for modeling PepPI predictions that effectively learns the pattern of pairwise local interactions, enables the identification of key residues participating in the peptide-protein interactions, and offers an intuitive approach to interpret the underlying mechanisms of PepP...
Shuaiyan Li, Xiaorui Wang, Yuchen Zhu et al.· Journal of Chemical Informat...· 4 citations
PepPCBench enables a robust evaluation of PFNN-based methods and supports their continued development for peptide-protein structure prediction, and highlights the influence of peptide length, conformational flexibility, and training set similarity on prediction accuracy.
Si-Long Zhai, Huifeng Zhao, Ji-Ke Wang et al.· Journal of Chemical Informat...· 13 citations· ⚡1
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
