Results suggest that CRB-701 may be a promising alternative therapeutic for the treatment of nectin-4 expressing tumors, providing a more favorable therapeutic window and potentially enabling regimens with higher doses and less frequent dosing than are required for EV, the only currently approved nectin-4 targeting ADC...
Zhao-Peng Sun, Mo Dan, Lu Lv et al.· Cancer Research Communicatio...· 0 citations
EvoMax is established as an integrated strategy for engineering compact eukaryotic Fz2 genome editors and FanzMAX v3-hLa is identified as a high-efficiency programmable nuclease for mammalian genome editing.
Shijie Wan, J. Gold, Pranay Vure et al.· Nature Biotechnology· 1 citation
The LSN-based mild solubilization and chromatographic purification process developed in this study successfully circumvents the destructive effects and complex refolding steps associated with conventional strong denaturants, and the prepared recombinant His-VP1 protein possesses the potential to serve as a high-quality...
Lei Fan, Jianpeng Liang, Jieshan Lin et al.· Sheng wu gong cheng xue bao...· 0 citations
Photodynamic inactivation (PDI) offers a green, non-thermal and sustainable strategy for controlling foodborne pathogens and spoilage microorganisms in animal-derived foods, and natural products are increasingly being explored as photosensitizers. Here, we identify the previously underexplored photodynamic antibacteria...
Lin Yang, Kai-Yuan Su, Zhuo-Ran Guo et al.· Food Research International· 0 citations
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HRP/Eo crosslinking method is identified as a favorable strategy for engineering dECM particle–THA hydrogels for cartilage regeneration and improved mechanical performance and chondrocyte redifferentiation effect compared to SPS/Ru, attributed to the difference in hydrogel morphology.
Jiang-Yao Xu, Jacek K. Wychowaniec, M. D’Este et al.· RSC Advances· 0 citations
The PTM‐related six‐gene model showed potential for prognostic stratification and characterization of immune‐related features in LUAD and demonstrated that the low‐risk group may be more likely to benefit from immunotherapy.
Zhi Liu, Gang Li, Ling Lin· Human Mutation· 0 citations
A strategic platform that combines a novel ultrasensitive magnetic resonance (MR) contrast agent with deep learning to significantly enhance the tumor‐to‐normal ratio (TNR) and enabled the reconstruction of three‐dimensional tumor models, offering clinicians an intuitive visualization of tumor structure for precise dia...
Jiaying Zheng, Yi Zhu, Xin-Rui Li et al.· Advancement of science· 0 citations
Deep proteomic profiling of human carotid plaques identifies molecular signatures of symptomatic atherosclerosis that extend beyond conventional histopathology, which implicate neutrophil activation and inflammatory signaling pathways as key determinants of plaque vulnerability.
L. Zhang, L. Živković, A. Ray et al.· medRxiv· 0 citations
The 1H, 13C, and 15N resonance assignments of the Amblyomin-X Kunitz domain obtained by multidimensional NMR spectroscopy provide the first detailed NMR characterization of the Amblyomin-X Kunitz domain l.
Vitor S. Almeida, Virginnia C. Nogueira, L. S. O. Conti et al.· Biomolecular NMR Assignments· 0 citations
A protein CT analysis plugin for PyMOL v3.6.1 with a graphical user interface (GUI), automatic installation, and novel features developed through integration with PyMOL’s application programming interface (API).
Matīss Dimiņš, Alexander Bazba, Ádám Mogyorósi et al.· bioRxiv· 0 citations
This study enhances the understanding of the E. coli-genome nature and suggests the existence of specific and experimentally testable novel prions in this organism, and moves a step forward towards the identification of new prion proteins in bacteria.
Katherine Shreeve, Jinoh Jang, Mr. S Srivathsan et al.· Proteins: Structure, Functio...· 0 citations
Milk proteins deliver nutritional, functional, and bioactive properties that alternative protein sources cannot adequately replicate, yet conventional livestock-based production faces compounding constraints of scalability, resource intensity, and sustainability. Precision fermentation offers a structurally distinct so...
Zhengtao Guo, Kun Ye, Zhen-Ye Shi et al.· Comprehensive Reviews in Foo...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
