FINDING: Viral capsid geometry is governed by the Caspar–Klug triangulation number T = h² + hk + k², with the golden ratio emerging from pentagonal symmetry constraints, not from arbitrary decoration. | MATH: T = h² + hk + k² (h,k non-negative integers, not both zero). Icosahedral symmetry group: A₅ (order 60). Pentago...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Completes the Wang and Iha (2023) ferroptosis gene list. No analysis code changes. Correction results/wang_iha_degs.json held 45 of the 46 ferroptosis-related differentially expressed genes that Wang and Iha report (21 up, 24 down instead of 21 up, 25 down). The missing gene is GABARAPL1, downregulated, log2 fold chang...
Abdelmuhsen Abusneina· Zenodo (CERN European Organi...· 0 citations
Strategies for targeting adenomatous polyposis coli ( APC) loss-of-function ( APC -LOF) may provide an opportunity to intercept tumorigenesis in high-risk CRC patients, such as those with Familial Adenomatous Polyposis (FAP). Here, we uncovered a novel synthetic lethal dependency of APC -LOF on protein arginine methylt...
Dana S. Gaffney, Fabian Hulpia, Jan Willem Thuring et al.· Communications Biology· 0 citations
Inorganic polyphosphate (polyP) is a ubiquitous phosphate biopolymer involved in diverse cellular processes. Despite its significance, selective detection of polyP remains challenging because of its simple and highly charged structure. Here, we report a far-red fluorogenic turn-on chemosensor for selective polyP dete...
Kenji Torii, Ru̅ta Gerasimaitė, G. Lukinavičius· Journal of the American Chem...· 0 citations
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Postprandial glucose depends on the meal and the person consuming it. This exploratory secondary analysis used 1,047 isolated meals from 32 CGMacros participants with complete nutrition, clinical, microbiome, and Fitbit records to test whether information beyond macronutrients improved prediction for people excluded fr...
Riddhi Singhvi· Zenodo (CERN European Organi...· 0 citations
FINDING: Viral capsid geometry is governed by the Caspar–Klug triangulation number T = h² + hk + k², with the golden ratio emerging from pentagonal symmetry constraints, not from arbitrary decoration. | MATH: T = h² + hk + k² (h,k non-negative integers, not both zero). Icosahedral symmetry group: A₅ (order 60). Pentago...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Results indicate that combining protein language models with sequence modeling and class-imbalance learning strategies is an effective way to improve peptide hormone prediction and to improve the recognition of hormone peptides as the minority class.
Chun-Yan Ao, Shihu Jiao, Xi Su et al.· Journal of Advanced Research· 0 citations
Vocal fold injuries were repaired within seven days and results indicated that proliferate behavior differs between macula flava cells and fibroblasts during vocal fold injury repair.
Xu-Mao Li, Xiang-Yu Chen, Sen Yu et al.· Brazilian Journal of Otorhin...· 0 citations
ABSTRACT Chemically induced protein dimerisation (CID) is a widely used approach for detecting and actuating small‐molecule‐protein interactions. Here, we demonstrate that CID systems can be used as building blocks for higher‐order ligand‐controlled protein systems. To this end, we converted classical FK506‐ and cyclos...
Zhenling Cui, Zhong Guo, Yi Jin Liew et al.· Angewandte Chemie· 0 citations
The symbiotic skin bacterium Staphylococcus epidermidis moisturizes human skin, contributes to protection against external pathogens, and supports innate immune stimulation. However, the interaction between collagen, a major skin protein, and S. epidermidis remains insufficiently explored. In this study, biofilm develo...
Lipoate is an essential protein-bound cofactor attached to conserved lysine residues in structurally related acceptor proteins, including GcvH of the glycine cleavage system and LbpA proteins required for sulfur oxidation by the sulfur-oxidizing heterodisulfide-like (sHdr) complex. The coexistence of distinct lipoylati...
Carolin Kümpel, Emma Holz, Tomohisa Sebastian Tanabe et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Human milk (HM) is recommended for infants, as it provides essential nutrients and folded whey proteins, including lactoferrin (LF), that perform antimicrobial functions and aid in gut development. However, many rely on infant formulas (IFs), where there are no clear data on how much folded whey protein is present. W...
J. C. Devenport, Jackson Tower, Charity C. Jennings et al.· Journal of Agricultural and...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
