A substantial fraction of human proteins have no described function. C17orf58 (UniProt Q2M2W7; "UPF0450 protein C17orf58") is one of them: it has no experimental structure and no functional literature. Here I report a computational characterization of C17orf58 that combines structure prediction, structural homology sea...
Aayush Shah· Zenodo (CERN European Organi...· 0 citations
A substantial fraction of human proteins have no described function. C17orf58 (UniProt Q2M2W7; "UPF0450 protein C17orf58") is one of them: it has no experimental structure and no functional literature. Here I report a computational characterization of C17orf58 that combines structure prediction, structural homology sea...
Aayush Shah· Zenodo (CERN European Organi...· 0 citations
Previously, we reported ITE-derived bioisostere 2-(1
H
-indole-3-carbonyl)-N-methyl thiazole-4-carboxamide (ITE-CONHCH
3
) as a high-affinity ligand and potent agonist of the aryl hydrocarbon receptor (AhR) with anti-colitis properties. In the current study, we present its initial
in vitro
pharmacological profi...
Zdeněk Dvořák, Aneta Grycová, R. Vrzal et al.· Frontiers in Pharmacology· 0 citations
Abstract Protein disulphide formation between cysteine residues impacts protein folding and function, yet the context in which it occurs often determines whether it is beneficial or detrimental. To ensure proper disulphide status, organisms have evolved compartment-specific disulphide maintenance systems. Some of these...
J. D. West· Philosophical transactions o...· 0 citations
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COS plasma membrane acts as a shunt conducting free transmembrane proteins between lamellae by Brownian diffusion, even in the presence of crowding effects and complex membrane geometry, while lamellae are capacitive sources/sinks.
A. Tokarev, Peter D. Calvert· Biophysical Journal· 0 citations
This work provides the first systematic comparison of MRM, MS3, and in-source CID for PPG quantification, establishing a sensitive analytical platform with complementary greenness and practical applicability assessments using AGREE, AGSA, CACI, and GEMAM, for polymer bioanalysis in complex matrices.
Jia-Rui Zhang, Zi-Chan Tian, Jin-Qing Wu et al.· In Analysis· 0 citations
High-resolution structure determination of RNA remains a major challenge due to its conformational flexibility, intrinsic heterogeneity, and susceptibility to degradation. Although RNA plays central roles in gene regulation, viral replication, and cellular homeostasis, RNA-only structures represent a small fraction of...
Jerricho Tipo, K. Gottipati, Marc C. Morais et al.· Journal of Biological Chemis...· 0 citations
Haplo-identical hematopoietic cell transplantation (haploHCT) is an integral treatment paradigm for patients with leukemia. While overall survival (OS) post-haploHCT has steadily improved, relapse-free survival (RFS) remains relatively stagnant. Upon the discovery of killer immunoglobulin-like receptors (KIRs) on natur...
S. Gottschalk, Ying Li, S. Selukar et al.· Blood Advances· 0 citations
Abstract Disruption of protein homoeostasis, or proteostasis, is a hallmark of protein conformational diseases (PCDs), including Alzheimer's and Parkinson's disease. These disorders are characterized by progressive protein aggregation and cellular dysfunction, yet no effective therapies exist. Emerging evidence indicat...
Daniel M. Czyż, Brittani M. Brown· Philosophical transactions o...· 0 citations
Abstract Proteostasis, the process governing the dynamic regulation of protein synthesis, folding and degradation, is critical for maintaining cell function and organismal health. Ageing disrupts this intricate system, leading to inactive, misfolded and/or aggregated proteins that contribute to age-associated pathologi...
Neethu Babu, Katie L. Whalen, Brian Freeman· Philosophical transactions o...· 1 citation
Tacabrutideg demonstrates potent preclinical activity in MZL as a single agent and in combination regimens, and together with the superior activity of sonrotoclax, these findings provide a strong rationale for the clinical evaluation of dual BTK degradation and BCL2 inhibition in patients with MZL.
A. Arribas, Alex Zadro, E. Civanelli et al.· Haematologica· 0 citations
Clinical features, diagnosis, genetics, and management of FBPase deficiency are summarized, with particular emphasis on the functional interpretation of FBP1 variants and the broader biological roles of FBP1.
Ikki Sakuma, Gerald I. Shulman, Tomoaki Tanaka· Endocrine journal· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
