In this study, we evaluated the effects of a probiotic supplement in distiller’s dried grains with solubles (DDGS) feeds on the hepatic transcriptome of Berkshire finisher pigs. At high levels, DDGS has been shown to reduce nutrient utilization, cause inflammation, and result increased adipose tissue which reduces ca...
D. Coble, Brianna J. Carter, Ayanna J. Harrison et al.· Journal of Animal Science· 0 citations
The rapid emergence of global antimicrobial resistance (AMR) has outpaced the development of new antimicrobial agents, necessitating transformative approaches such as AI-driven in-silico drug discovery. Antimicrobial peptides (AMPs) are promising alternatives due to their broad-spectrum bactericidal activity and limite...
Naveed Saleem, E. El-Omar, Naresh Kumar et al.· Frontiers in Cellular and In...· 0 citations
Chronological age can be estimated from molecular profiles; however, predictive accuracy alone does not establish a biologically validated ageing clock. We therefore evaluated whether plasma protein intensities measured by data-independent acquisition mass spectrometry (DIA-MS) support chronological-age estimation in a...
M. Arbatskiy, D. Balandin, S. Novikova et al.· International Journal of Mol...· 0 citations
A previously undescribed polysaccharide was isolated from the edible mushroom Russula adusta. Structural analysis showed that Russula adusta polysaccharide (RA‑P) has a molecular mass of 20,576 Da and main chain consists of (1→4,6)-Glcp, (1→4)-D-Glcp, (1→4)-D-Galp and (1→6)-Galp remnants, with side chain →1)-Galp and a...
Shu-Rong He, Xin-Lin Li, Jie Tang et al.· Chiang Mai Journal of Scienc...· 0 citations
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Plasma betaine and its downstream metabolites, N,N-dimethylglycine, sarcosine and serine, and its downstream metabolites, N,N-dimethylglycine, sarcosine and serine, were greater in BET than in CTRL, suggesting a potential sparing effect.
Amelia M. Huebsch, J. Pezzali· Journal of Animal Science· 0 citations
Feed efficiency (FE) is a complex trait with major implications for the sustainability and profitability of dairy production; however, the potential association of the milk-associated microbiota with this phenotype remains largely unexplored. Additionally, milk somatic cells (MSC) provide a minimally invasive and eas...
Á. Cánovas, Guilherme Henrique Gebim Polizel, Le-Luo Guan et al.· Journal of Animal Science· 0 citations
Recombinant proteins are the workhorse of modern biochemical research, yet their use
in vitro
is routinely questioned on grounds of physiological relevance. Here we provide a structured guide to the strengths and limitations of recombinant protein studies, framed within the broader contrast between systemic (top-do...
D. Dell'Orco, Karl-W Koch· Frontiers in Molecular Biosc...· 0 citations
Post-traumatic stress disorder (PTSD) is associated with immune and autonomic disturbances, but molecular programs linking PTSD-related blood transcriptional signals with autonomic–cardiac biology remain incompletely characterized. The public Gene Expression Omnibus (GEO) cohorts analyzed here did not directly measure...
Yi-Han Guo, Dong-Dong Shi, Lan-Ying Liu et al.· International Journal of Mol...· 0 citations
In cases of subjects with ITP, there was a marked reduction in the counts and indices of platelets and expression of the PTPN22 gene, and other indicators, including ANA, IL-37, IL-40, PA-Ab, rs2488457, and rs1395448650 were not significantly linked to ITP.
Sarah Nabeel Lamam, S. R. Ibraheem· Iraqi Journal of Hematology· 0 citations
Self-supervised pre-training has become the dominant paradigm in single-cell and protein modelling, yet its value for microbiome-based disease classification remains untested under evaluation protocols that control for study-level confounding. Public metagenomic collections aggregate hundreds of independently conducted...
Khaled Sayed· Zenodo (CERN European Organi...· 0 citations
Pancreatic ductal adenocarcinoma (PDAC) accumulates vast amounts of hyaluronic acid (HA), generating a rigid, high-pressure stroma that blocks drug delivery and infiltration. Although hyaluronidase (HAase) can dismantle this barrier, systemic administration of HAase depletes HA from healthy tissues and causes dose-limi...
Background: Cytokine Release Syndrome (CRS) is a major driver of acute organ failure in critical care settings, affecting approximately 49 million people and killing approximately 11 million people annually. Targeting multiple dysregulated feedback loops via single-molecule polypharmacology offers a promising strategy...
Leo Meng, Valentina L. Kouznetsova, Santosh Kesari et al.· ChemRxiv· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
