It is demonstrated that CBD-IL-12 exhibited 4-fold enhanced tumor accumulation compared to unmodified IL-12 and increased cytotoxic T cell infiltration by 2.2-fold within the immune-cold microenvironment in a mouse model of OS.
Takumi Matsuo, Laurine Noblecourt, Pooja Kaur et al.· Journal of Controlled Releas...· 0 citations
Reward maximization alignment methods for discrete diffusion models have primarily focused on steering the reverse process, either by influencing token logits or by selecting favorable sequences at intermediate steps. These approaches largely treat inference as a unidirectional process, lacking mechanisms for revisitin...
Shai Dickman, M. Cemri, Landon Butler et al.· 0 citations
This study explored the effects of micro-nano bubble (MNB) pretreatment combined with Lactiplantibacillus plantarum (Lp) fermentation or lipase (Lip) hydrolysis on lamb meat quality, gel properties, and flavor. SEM revealed that MNB loosened muscle fibers and increased porosity, while FT-IR indicated that MNB alone did...
Meijuan Xu, Xinfeng Yue, Yuxian Liu et al.· Food Chemistry X· 0 citations
This proposal builds upon the foundation established in BAG MX 2521 and MX 2644 and represents a collaborative effort among prominent Swiss academic institutions, including EPFL, UNIL, UNIGE, university of Zurich and SLS. Under the leadership of Dr. Florence Pojer, the head of the Protein Production and Structure core...
Florence Pojer· European Synchrotron Radiati...· 0 citations
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In this study, we assessed the effects of a non-linear cold stress experiment on the physiology and metabolite profiles of the emerging sea anemone model system Aiptasia couchii. This repository hosts Supplementary Tables S1-S7 along with Supplementary Files S1-S4 which contain R scripts used for the analyses. Manuscri...
Marie Legain, Taissa Lopes Damasceno, Slimane Chaïb et al.· Zenodo (CERN European Organi...· 0 citations
The results reveal a new C-terminus-mediated RPA-RecQ interaction in L. donovani that resembles the prokaryotic SSB-RecQ interaction mechanism, while maintaining functional conservation of eukaryotic DNA metabolism.
Mayukh Chakraborty, Susmita Ghosh, Surasree Chakraborty et al.· The FEBS Journal· 0 citations
Metata Ayib
is a traditional Ethiopian spiced fermented hard cheese produced through spontaneous anaerobic fermentation of cottage cheese (
Ayib
) with various spices. This critical review, the first comprehensive synthesis of research on
Metata Ayib
, critically evaluates the available literature to assess it...
In this study, we assessed the effects of a non-linear cold stress experiment on the physiology and metabolite profiles of the emerging sea anemone model system Aiptasia couchii. This repository hosts Supplementary Tables S1-S7 along with R scripts used for the analyses. Manuscript status: accepted for publication in M...
Marie Legain, Taissa Lopes Damasceno, Slimane Chaïb et al.· Zenodo (CERN European Organi...· 0 citations
An enhanced CgCas12n system (eCgCas12n) is established that enables efficient mammalian genome editing and provides an efficient genome- and base-editing platform for functional genetic studies.
Bo-Wen Hou, Xin-Yi Liu, Jia-Wen Fan et al.· Molecular Systems Biology· 0 citations
This surface-anchored customized curli nanofiber probiotic integrates high-affinity lead chelation with the bioactivities of a living biointerface, offering a safe, oral, and programmable platform for the holistic management of lead poisoning.
Jin-Yun Hong, Bo-Chuan Yuan, Han-Xiao Feng et al.· ACS Applied Materials and In...· 0 citations
Reliable screening and discrimination between multifloral and monofloral honeys are important for supporting honey quality assessment, consumer confidence, and market transparency. In this study, the potential of physicochemical parameters combined with machine learning techniques was investigated for the binary clas...
H. Sahin, A. E. Tanuğur-Samancı, Esra Birinci et al.· Scientific Reports· 0 citations
This work explored how the guide RNA of CRISPR genome editing system folds and modulates its structural flexibility to carry out the roles required for each assembly state from its unbound apo form to the functional Cas9 RNP state for target DNA cleavage using ABEL-FRET spectroscopy.
Bok-Eum Choi, Hugh Wilson, Quan Wang· bioRxiv· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.