Selenium (Se) is an essential trace element required for numerous physiological processes, including antioxidant defense, redox homeostasis, immune regulation, thyroid hormone metabolism, and endoplasmic reticulum function. The biological activities of Se are primarily mediated through its incorporation into selenoprot...
Fatema Suliman Alatawi, Engy Mahmoud Mowafy, Ibrahim Youssef et al.· Egyptian Journal of Basic an...· 0 citations
The Coherence Maintenance Framework (CMF), established in Papers 1 and 2, demonstrates that threshold-gated regulatory architecture is a universal feature of driven non-linear systems across 29 orders of magnitude in scale. While R_mode = f_pert * tau_relax quantitatively categorizes regulatory dynamics into discrete o...
David Matthews· Zenodo (CERN European Organi...· 0 citations
Twenty protein kinase-like (PKL) superfamily families new to this genome collection are identified, demonstrating enzymatic specialization, adaptation specific to pathogens and structural co-option.
Marianna Krysińska, Weronika Śliczniak, Z. Jakubowska et al.· bioRxiv· 0 citations
Short-duration exposure (SDE) of antibiotics is among the major drivers of the emergence of antimicrobial resistance (AMR) among bacterial pathogens. Klebsiella pneumoniae is a critical priority bacterial pathogen and rapidly acquiring MDR/XDR traits even against major antibacterial classes of antibiotics. Since colist...
ABSTRACT Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are ESKAPE pathogens that are responsible for severe skin and soft tissue infections (SSTIs), particularly in the elderly and those with immunocompromising conditions. Rising rates of methicillin-resistant S. aureus (MRSA) and carbapenem-resistant PA h...
Suhrid Maiti, T. Lu, Zackary Dietz et al.· Infection and Immunity· 0 citations
ABSTRACT Microplastics (MPs) and nanoplastics (NPs) have emerged as ubiquitous environmental contaminants with profound implications for human neurological health. Recent landmark findings confirm the bioaccumulation of MPs/NPs in human brain tissue—with concentrations reaching 4917 μg/g in 2024 autopsy samples and up...
Alfi Sophian, Asmariani, Erika Ismayani· Journal of biochemical and m...· 0 citations
We propose that a single information-theoretic operation — the many-to-one map on a physical system's state space, followed by inaccessibility of the discarded alternatives — is the missing universal principle underlying defmiteness, selection, irreversibility, and the emergence of classical structure across every scal...
Scott G J Devine· Zenodo (CERN European Organi...· 0 citations
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) poses a significant public health threat, with a fatality rate of 37% and no approved therapeutics (World Health Organization, 2026). Non-structural protein 10 (nsp10) is an essential cofactor that activates both the nsp14 3’-5’ exoribonuclease (ExoN) activity req...
D. Dong, F. Kozielski, Christopher A. Waudby· bioRxiv· 0 citations
Background/Objectives: The very low-density lipoprotein receptor (VLDLR) mediates VLDL uptake in peripheral tissues. This study investigated sex differences in hepatic VLDLR response to protein restriction and its relationship with hepatic lipid accumulation. Methods: Male and female wild-type (WT) and Vldlr knockout (...
Statistical analysis of protein crystallization outcomes in the final TargetTrack release (1 July 2017; 52,307 purified structural-genomics targets across 17 centres, within-centre models). Finding: at equal net-charge magnitude, positively charged proteins are recorded as crystallized less often than negatively charge...
LI-CHI CHANG· Zenodo (CERN European Organi...· 0 citations
This study systematically revealed shared differential expression trends and immune-related pathway enrichment features between ANCA‑GN and IgG4‑RD at the transcriptomic level, and identified ITGAM and CXCL1 as potential cross-tissue candidate biomarkers, offering novel insights into the transcriptomic‑level cross-tiss...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
