TL;DR
It is indicated that chrysin treatment is associated with selective cytotoxicity and concurrent modulation of HPV16 E6 protein levels and several cancer-related miRNAs in CaSki cells.
CEO exerts selective cytotoxic and antiproliferative effects on cervical cancer cells by triggering mitochondria-mediated apoptosis and suppressing HPV oncogenes, support CEO as a potential source of bioactive compounds for complementary strategies against HPV-related malignancies.
Despite being preventable, cervical malignancy remains a major cause of mortality among women,particularly in low-resource settings with limited screening availability. Although high-risk humanpapillomavirus (HPV) types 16 and 18 are the primary causative agents, malignant progressionoccurs in only a minority of cases,...
Cervical cancer is a leading cause of female malignancy worldwide. While microRNA-4327 (miR-4327) has been implicated as a potential oncogene, its functional role and molecular mechanisms in cervical cancer pathogenesis remain unclear. This study aimed to determine the oncogenic function of miR-4327 and elucidate its d...
Novel insights are provided into the nature and progression of prostate tumors and the role of miRNA-330 as a biomarker, indicating a clear correlational effect of latent human Papillomavirus type 16 infection.
This finding suggests that probiotics can effectively downregulate certain oncomiRs and enhance their target tumor suppressor genes and protein levels, and the down-regulation of oncomiRs may display positive effects of probiotics, leading to inhibition of tumor growth and anti-proliferative outcomes.
Functional studies demonstrated that IFI35 knockdown effectively suppressed BRCA cell proliferation, migration, and invasion, while promoting apoptosis, and is a potential therapeutic target for BRCA.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
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