Aug 2026· Journal of Applied Clinical Medical Physics· Vol 27 9, pp.
e70774
· 0 citations· 17 references
Medicine
Abstract
Background
Total skin electron therapy (TSET) is a standard treatment for cutaneous T-cell lymphoma. Due to the complex patient positioning and irregular body contours, robust in-vivo dosimetry (IVD) is essential to verify dose uniformity. While thermoluminescent dosimeters (TLDs) are traditional standard, their utility is hindered by labor-intensive, manual processing.
PURPOSES
This study evaluates the clinical implementation of a Gafchromic™ EBT4 film-based IVD system integrated with a bespoke, open-source analysis platform for automated batch-processing. To address the inherent orientation dependence and loss of film orientation frequently encountered when preparing small-format IVD films with a manual paper cutter, we developed an orthogonal dual-scan protocol. By averaging pixel values from two perpendicular scans for both calibration and clinical measurement, this protocol effectively mitigates orientation-dependent uncertainties and ensures dosimetric robustness.
Methods
The film-based IVD system was clinically assessed in five TSET treatments and compared to six treatments utilizing TLD-based IVD. Dosimetric accuracy was evaluated by comparing normalized fractional doses to the prescription. Statistical analysis was performed using the Mann-Whitney U test with the Benjamini-Hochberg procedure to control the false discovery rate across 20 anatomical sites. Workflow efficiency was quantified by the total time required for data readout and analysis per patient.
Results
The EBT4 film-based IVD demonstrated dosimetric accuracy comparable to the TLDs, with mean fractional doses of 102.7% ± 9.6% and 100.4% ± 9.7%, respectively (p = 0.25). Clinical implementation of the film-based approach significantly enhanced efficiency, reducing the total processing time from approximately 50 min to 15 min per treatment.
Conclusions
The proposed EBT4 film-based IVD system, supported by open-source software and an orthogonal dual-scan protocol, offers a robust, cost-effective, and time-efficient alternative to traditional TLDs. This approach streamlines the clinical workflow without compromising dosimetric accuracy, making it a viable solution for TSET and broader radiotherapy IVD applications.
MAGE explains how externalized knowledge, bounded action, independent evaluation, and retained human authority can compose into a governed engineering environment, and proposes tests of when that environment turns commodity intelligence into durable engineering progress.
James C. Davis, Kelechi G. Kalu, Huiyun Peng et al.· 1 citation
LLMs are increasingly used for code generation, yet they frequently hallucinate non-existent software packages, creating exploitable entry points into the software supply chain. We make four contributions to this problem. First, we show that prior evaluation methodologies systematically inflate hallucination rates by misclassifying standard-library modules as hallucinations in some languages. For Python, the overestimation reaches 9.4 percentage points. Second, we evaluate seven inference-time defenses for mitigating package hallucinations, including five guided decoding strategies (Greedy, Contrastive, DoLa, Nudging, and Active Layer-Contrastive Decoding), an iterative self-refinement approach (Self-Refine), and a Retrieval-Augmented Generation (RAG)-based defense.. Across eight models spanning five families and four programming languages (Python, JavaScript, Ruby, Rust), RAG reduces the package hallucination rate (PHR) in 18 of 32 model--language configurations. Third, we introduce Package Utility (PU) to assess whether defenses preserve valid and task-relevant recommendations. Among strategies evaluated, Greedy decoding provides the strongest average mitigation--utility trade-off. Fourth, we stress-test all strategies under adversarial prompts seeded with fabricated package names and find that PHR surges by up to 45 percentage points relative to standard prompts, with Ruby consistently the most vulnerable language (80.9--95.2\%). Under adversarial conditions, RAG and Self-Refine outperform all decoding-only strategies, indicating that robust defense requires either external grounding or iterative self-verification when prompts are actively hostile. Our results recast package hallucination as both a measurement problem and a decoding-time control problem, and they demonstrate that the choice of defense must be matched to the threat model and recommendation utility.
Albérick Euraste Djiré, Iyiola E. Olatunji, Melissa Tessa et al.· 1 citation
HawkEye is introduced, a modular, web-based vulnerability auditing platform designed to streamline security analysis by integrating multiple scanning tools within a unified dashboard and illustrates how consolidated reporting improves vulnerability prioritization for development teams.
D. R. Patil, Varad Salgare, Devaj Arya et al.· International Journal for Re...· 0 citations
By streamlining workflows and fostering collaboration, this platform offers a scalable, cost- effective solution for SMEs and contributes to software engineering by demonstrating how integrated technologies can modernize development processes in resource limited contexts, with potential for broader adoption in Albania and beyond.
OBJECTIVE
To prospectively evaluate whether modifying DSL version 5-based hearing aid (HA) fittings by adjusting gain on HA fitting software so that measured functional gain (FG) approached a one-third gain (1/3G) target could provide appropriate fitting outcomes in patients with sensorineural hearing loss.
METHODS
Twenty-four patients (48 ears) with bilateral sensorineural hearing loss underwent initial HA fitting using the DSL version 5 prescription formula. FG was measured at 250-4000 Hz, and HA gain was adjusted on HA fitting software so that FG approached the target 1/3 G. Speech discrimination scores at 65 and 80 dB SPL were evaluated after a two-week trial period using the 67-S Japanese monosyllable word list. Based on speech discrimination test results, ears were classified as well-fitting or non-well-fitting. FG values were compared between the two groups.
RESULTS
Twenty-one patients (42 ears) completed the study. Thirty-one ears (73%) were classified as well-fitting. Although HA gain was adjusted toward the target 1/3 G, measured FG values at 250 and 500 Hz remained lower than the target values. In well-fitting ears, low-frequency FG values were lower than the target 1/3 G, whereas FG at 2000 Hz was close to the target value. In contrast, non-well-fitting ears showed low-frequency FG values closer to the target 1/3 G, whereas FG values at 2000 and 4000 Hz remained below the target values.
CONCLUSIONS
Although HAs adjusted toward a 1/3 G target did not achieve the intended FG values, particularly at low frequencies, relatively favorable fitting outcomes were obtained in approximately three-quarters of the ears. In well-fitting ears, low-frequency FG remained below the target 1/3 G, whereas FG in the mid-frequency range around 2000 Hz was close to the target value. These findings provide a basis for future prospective studies to clarify how these FG characteristics should be applied to optimize HA adjustment.
A USAF cadet and a Lincoln Laboratory researcher found AI chatbots can help nontechnical service members produce viable software applications for their unique problems.